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1578: Medium Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
September 28, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
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  2. Avatar for Contenders 2. Contenders 63 pts. 13,087
  3. Avatar for Gargleblasters 3. Gargleblasters 37 pts. 13,078
  4. Avatar for Beta Folders 4. Beta Folders 21 pts. 12,979
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  8. Avatar for Russian team 8. Russian team 1 pt. 12,063
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  10. Avatar for L'Alliance Francophone 10. L'Alliance Francophone 1 pt. 11,718
  1. Avatar for pielie 81. pielie Lv 1 1 pt. 7,122
  2. Avatar for EALs DAD 82. EALs DAD Lv 1 1 pt. 6,065
  3. Avatar for atlas100 83. atlas100 Lv 1 1 pt. 6,023
  4. Avatar for JasperD 84. JasperD Lv 1 1 pt. 5,922
  5. Avatar for dana1899 85. dana1899 Lv 1 1 pt. 5,805
  6. Avatar for Whateverwater 86. Whateverwater Lv 1 1 pt. 5,709
  7. Avatar for MadCin 87. MadCin Lv 1 1 pt. 5,422
  8. Avatar for jwilson04 88. jwilson04 Lv 1 1 pt. 4,565
  9. Avatar for Odena 89. Odena Lv 1 1 pt. 4,528
  10. Avatar for multaq 90. multaq Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +480)
Penalizes extra residues inserted beyond the starting 75, at a cost of 32 points per residue. Players may use up to 90 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.