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1581: Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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    1. Gargleblasters
    100 pts. 12,570
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  1. Avatar for georg137 31. georg137 Lv 1 20 pts. 11,912
  2. Avatar for isaksson 32. isaksson Lv 1 19 pts. 11,910
  3. Avatar for Blipperman 33. Blipperman Lv 1 18 pts. 11,903
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  5. Avatar for drumpeter18yrs9yrs 35. drumpeter18yrs9yrs Lv 1 16 pts. 11,856
  6. Avatar for orily1337 36. orily1337 Lv 1 15 pts. 11,754
  7. Avatar for guineapig 37. guineapig Lv 1 14 pts. 11,746
  8. Avatar for Marvelz 38. Marvelz Lv 1 13 pts. 11,744
  9. Avatar for fpc 39. fpc Lv 1 12 pts. 11,687
  10. Avatar for NinjaGreg 40. NinjaGreg Lv 1 11 pts. 11,677

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +320)
Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.