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1581: Small Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
October 03, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Gargleblasters
    100 pts. 12,570
  2. Avatar for Contenders 2. Contenders 68 pts. 12,461
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 44 pts. 12,446
  4. Avatar for Beta Folders 4. Beta Folders 27 pts. 12,383
  5. Avatar for Marvin's bunch 5. Marvin's bunch 16 pts. 12,334
  6. Avatar for Go Science 6. Go Science 9 pts. 12,224
  7. Avatar for Void Crushers 7. Void Crushers 5 pts. 12,200
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 3 pts. 11,964
  9. Avatar for Russian team 9. Russian team 1 pt. 11,630
  10. Avatar for Deleted group 10. Deleted group pts. 10,413
  1. Avatar for stomjoh 41. stomjoh Lv 1 10 pts. 11,659
  2. Avatar for Anfinsen_slept_here 42. Anfinsen_slept_here Lv 1 10 pts. 11,648
  3. Avatar for vakobo 43. vakobo Lv 1 9 pts. 11,630
  4. Avatar for toshiue 44. toshiue Lv 1 8 pts. 11,619
  5. Avatar for jausmh 45. jausmh Lv 1 8 pts. 11,618
  6. Avatar for YGK 46. YGK Lv 1 7 pts. 11,606
  7. Avatar for Deleted player 47. Deleted player pts. 11,599
  8. Avatar for Maerlyn138 48. Maerlyn138 Lv 1 6 pts. 11,592
  9. Avatar for WBarme1234 49. WBarme1234 Lv 1 6 pts. 11,534
  10. Avatar for momadoc 50. momadoc Lv 1 5 pts. 11,489

Comments

bkoep Staff Lv 1

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +320)
Penalizes extra residues inserted beyond the starting 65, at a cost of 32 points per residue. Players may use up to 75 residues in total.

Secondary Structure (max +500)
No more than 10% of residues may form helices. Extra helices are penalized at 10 points per residue.