Foldit

1669: Extra Small Monomer Design

Closed since almost 7 years ago

Summary

Created: April 30, 2019
Expires: May 08, 2019 at 23:00 UTC
Max points: 100

Description

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 55 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. FoldIt@Netherlands 2 pts. 11,439
12. DW 2020 1 pt. 11,366
13. HMT heritage 1 pt. 11,278
14. Team South Africa 1 pt. 11,210
15. freefolder 1 pt. 11,066
16. MBB190 1 pt. 10,239
17. I3L GANG 1 pt. 10,184
18. Deleted group pts. 0

31. phi16 Lv 1 31 pts. 11,736
32. Vinara Lv 1 30 pts. 11,724
33. jobo0502 Lv 1 28 pts. 11,720
34. MicElephant Lv 1 27 pts. 11,694
35. christioanchauvin Lv 1 26 pts. 11,648
36. Merf Lv 1 25 pts. 11,643
37. stomjoh Lv 1 24 pts. 11,638
38. poiuytrewq987 Lv 1 23 pts. 11,612
39. Blipperman Lv 1 22 pts. 11,607
40. smilingone Lv 1 21 pts. 11,568

Comments

bkoep Staff Lv 1

April 30, 2019

Residue IE Score (max +500)
Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design (max +500)
Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count (max +275)
Penalizes extra residues inserted beyond the starting 60, at a cost of 55 points per residue. Players may use up to 65 residues in total.

Secondary Structure (max +500)
No more than 50% of residues may form helices. Extra helices are penalized at 10 points per residue.