Foldit Puzzles

2637: KCNT2 Round 9

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2636: Electron Density Reconstruction 127

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

2635: Revisiting Puzzle 141: Rosetta Decoy 5

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2634: KCNT2 Round 8

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2633: Electron Density Reconstruction 126

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. This puzzle is related to the one given previously in 2631, so many facets will look similar. There's three separate protein chains here, one really big one and two smaller, so the Trim tool is recommended.

2632: Revisiting Puzzle 140: Rosetta Decoy 4

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. This protein contains four cysteine residues, but in this state only two of them are expected to oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2631: KCNT2 Round 7

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2630: Electron Density Reconstruction 125

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. There's three separate protein chains here, one really big one and two smaller, so the Trim tool is recommended.

2629: Revisiting Puzzle 139: Rosetta Decoy 3

This is a throwback puzzle to the early days of Foldit. This is a Crystal structure of a hypothetical protein and the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2628: KCNT2 Round 6

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.