Foldit Puzzles

2627: Electron Density Reconstruction 124

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. There's two copies of the protein here and it's big, so Trim tool is highly recommended.

2626: Revisiting Puzzle 138: Rosetta Decoy 2

This is a throwback puzzle to the early days of Foldit. Ubiquitin is a well-known protein that helps to regulate the natural turnover of proteins in the cell, and this starting structure is a model of the protein produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.

2625: KCNT2 Round 5

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2624: Electron Density Reconstruction 123

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. You might be wondering how this protein is stable- it's not the whole protein, just the part that was crystallized for solving, hence the strange shape. It's big, so the Trim tool is recommended.

2623: Revisiting Puzzle 137: Rosetta Decoy

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate the human immune response, and the starting structure is a Rosetta model. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2622: KCNT2 Round 4

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2621: Electron Density Reconstruction 122

Note- 2620 was a mistaken repeat, and this is the puzzle that was intended. The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. This is a transporter protein that helps certain small molecules cross the cell membrane, hence the interesting shape!

2620: Revisiting Puzzle 136: Cell Adhesion

This is a throwback puzzle to the early days of Foldit. This small protein, from the venom of the saw-scaled viper, interferes with the cellular adhesion machinery that allows blood clotting. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2619: KCNT2 Round 3

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2618: Revisiting Puzzle 135: E. coli

This is a throwback puzzle to the early days of Foldit. This protein comes from the bacteria Escherichia coli, but its function is still unknown! We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.