Foldit Puzzles

2657b: Electron Density Reconstruction 134

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

2656: Revisiting Puzzle 150: Rosetta Decoy 12

This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (without disulfides bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.

2655: KCNT2 Round 12

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2654: Electron Density Reconstruction 133

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

2653: Revisiting Puzzle 148: Rosetta Decoy 11

This is a throwback puzzle to the early days of Foldit. This small protein is a component of the major histocompatibility complex (MHC) which is essential to a functioning immune system. The starting structure is a Rosetta model. This protein contains two cysteine residues that are oxidized to form one disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.

2652: KCNT2 Round 11

KCNT2 is a sodium‑activated potassium channel that helps neurons reset after firing, keeping brain activity in check. Mutations in the KCNT2 gene can disrupt this balance and are linked to severe developmental and epileptic encephalopathies (DEE) and related seizure disorders.

2651: Electron Density Reconstruction 132

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

2650: Revisiting Puzzle 147: Rosetta Decoy 10

This is a throwback puzzle to the early days of Foldit. This protein is part of a signaling pathway that regulates sporulation in B. subtilis; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2649: NaV1.7 Round 3

NaV1.7 is a voltage-gated sodium channel that plays a key role in the generation and propagation of action potentials, especially in neurons involved in pain signaling. Genetic studies have revealed that loss-of-function mutations in NaV1.7 can result in congenital insensitivity to pain, while gain-of-function mutations are associated with severe, painful disorders. This makes NaV1.7 a promising therapeutic target for the development of non-addictive painkillers—a much-needed alternative to current opioid-based treatments.

2648: Electron Density Reconstruction 131

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.