Foldit Puzzles

1317: 75 Residue Monomer Design: Blueprint

This puzzle features the new Blueprint panel, which can be accessed from the Actions menu (or the Main menu in Selection Interface). See the blog for more information. Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1316: Unsolved De-novo Freestyle 92

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1315: Electron Density Reconstruction 2

Note: This puzzle was closed early due to a large number of crash reports.

1314: Revisiting Puzzle 80: Calcium Channel Blocker

This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1313: 85 Residue Monomer Design: Blueprint

Note: The starting structure has only 70 residues, but players are encouraged to add residues up to a total of 85! The disparity in residue number allows sharing of solutions from Puzzle 1302, which was posted with a faulty Residue Count filter and awarded no points. We apologize for any inconvenience!

1311: Hfq TB puzzle - fixed

Note: Due to a large number of crash reports, this puzzle has been made worth zero points. The puzzle will remain active, and players are encouraged continue playing the puzzle if they can. We will still analyze players solutions for scientific merit!

1312: Hfq TB puzzle - monomer subunit

This is the monomor subunit for puzzle 1311. If puzzle 1311 is crashing for you, this puzzle can serve as a substitute for 1311. When we gather solutions, we will use both the solutions from this puzzle and from 1312.

1310: Revisiting Puzzle 79: Pheromone

This is a throwback puzzle to the early days of Foldit. This pheromone protein is secreted by the protist E. raikovi to initiate conjugation, the exchange of genetic material between two cells. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1309: Unsolved De-novo Freestyle 91

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1308: Revisiting Puzzle 77: Copper Chaperone

This is a throwback puzzle to the early days of Foldit. This protein binds copper ions so that they may be transported safely to the cell compartments and enzymes that require them. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.