Foldit Puzzles

1162: Unsolved De-novo Freestyle 59

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1161: Revisiting Puzzle 112: Bovine

This is a throwback puzzle to the early days of Foldit. This particular protein is known as ubiquitin, and plays a prominent role in the protein degradation pathway. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1160: 70 Residue Monomer Design

This is a basic 70 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1159: gp120 Design: Frozen V3 Hairpin

This puzzle is very similar to Puzzle 1155, except that now the V3 hairpin is frozen in place. We would like players to redesign the residues surrounding the V3 hairpin to try to stabilize this conformation of the HIV-1 Env protein. This puzzle includes an Exploration filter to prevent players from straying far from the starting conformation.

1158: Revisiting Puzzle 111: Mouse

This is a throwback puzzle to the early days of Foldit. This protein is found in the nucleus of stem cells in mice, and is important for maintaining the pluripotency of the stem cell. The protein is modeled here as in a reduced environment, so no disulfide bonds are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1157: 60 Residue Monomer Design

Note: This puzzle has been closed due to a bug that prohibited the puzzle from loading.

1157b: 60 Residue Monomer Design

Note: This puzzle replaces Puzzle 1157 which was closed early due to a bug.

1152: Foldit vs. UMich Electron Density Challenge

The structure of this protein was recently solved by crystallographers in the Bardwell Lab at the University of Michigan. Before they publish the structure, they are challenging a class of undergraduate students to build a model into this unrefined density map - and they have invited Foldit players to participate! As a further challenge, both Foldit players and students are provided with the full sequence of the protein; however, note that some parts of the protein are disordered and will not occupy any electron density. Just like the UMich students, Foldit players will have four weeks to develop a protein model that fits this density. Fold this protein into the electron density map to see if you can outperform the UMich students - or even the crystallographers themselves as the UMich students did last year!

1156: Revisiting Puzzle 110: Turkey

This is a throwback puzzle to the early days of Foldit. This is a portion of a troponin protein found in the skeletal muscle of turkeys. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1154: Revisiting Puzzle 109: Pumpkin

This is a throwback puzzle to the early days of Foldit. This is a trypsin inhibitor in pumpkins. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.