Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
-
Closed since over 10 years agoThe structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!
-
Closed since over 10 years ago
1134: 60 Residue Symmetric Dimer Design: Satisfied H-bonds
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry1134: 60 Residue Symmetric Dimer Design: Satisfied H-bonds
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryIn this puzzle, the bonus for Hbond networks has been doubled, but only Hbond networks that are at least 75% satisfied will be rewarded. We've also amended this puzzle so that the Core Exists filters should be even easier to satisfy. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
-
Closed since over 10 years ago
This is a throwback puzzle to the early days of Foldit. This small domain is part of a larger protein found at high concentrations of the lens of the eye; historically, this protein was purified from the eyes of B. taurus for research. The protein is modeled here in reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.
-
Closed since over 10 years ago
1132: Unsolved De-novo Freestyle 56: Predicted Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts1132: Unsolved De-novo Freestyle 56: Predicted Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsUpdate: In response to a server outage, the expiration date of this puzzle has been extended to 09/06/2015 - 23:00 GMT.
-
Closed since over 10 years ago
1131: 60 Residue Symmetric Trimer: Satisfied H-bonds
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry1131: 60 Residue Symmetric Trimer: Satisfied H-bonds
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryUpdate: In response to a server outage, the expiration date of this puzzle has been extended to 09/04/2015 - 23:00 GMT.
-
Closed since over 10 years ago
Update: In response to a server outage, the expiration date of this puzzle has been extended to 09/02/2015 - 11:00 GMT. In order to receive credit for work completed during the outage, players should be sure to open this puzzle while playing online!
-
Closed since over 10 years ago
Note: This puzzle was erroneously posted with the wrong protein. It has been closed and replaced with Puzzle 1130b.
-
Closed since over 10 years ago
The structure of this protein is still unknown. The PSIPRED secondary structure predictions are provided on the starting model.
-
Closed since over 10 years ago
1128: 70 Residue Symmetric Dimer Design: Satisfied H-bonds
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry1128: 70 Residue Symmetric Dimer Design: Satisfied H-bonds
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryPlayers will need the latest update to play this puzzle! This puzzle is very similar to previous H-bond network puzzles, though the HBNet filter has been slightly tweaked. In this puzzle, the bonus for H-bond networks has been doubled, but only Hbond networks that are at least 75% satisfied will be rewarded. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
-
Closed since over 10 years ago
This is a throwback puzzle to the early days of Foldit. This small peptide is part of a larger protein that helps to regulate cell division, and is very important in early embryonic development. The protein is modeled here as in a reduced environment, so no disulfide bonds are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.