Foldit Puzzles

1183: Unsolved De-novo Freestyle 65

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1181: Revisiting Puzzle 126: Ethanolamine Utilization

This is a throwback puzzle to the early days of Foldit. This protein allows bacteria to metabolize ethanolamine and use it in constructing cell walls and cell membranes. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1180: Unsolved De-novo Freestyle 64

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1179: 70 Residue Symmetric Dimer Design: H-Bond Networks

In this symmetric design puzzle, we're requiring a few more residues to buried in the whole complex (either within the monomer unit or at the interface). The Hbond Network Filter encourages players to bury satisfied Hbond networks at the interface, but note that no more than four inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1178: Revisiting Puzzle 125: Ice Binding

This is a throwback puzzle to the early days of Foldit. This protein is found in cold water fishes; it binds and prevents the growth of ice crystals. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1177: Unsolved De-novo Freestyle 63

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1174: 70 Residue Symmetric Hexamer Design: Protein Snowflakes

This is a symmetric hexamer design puzzle with 70 residues; there will be six symmetric chains to manage. This puzzle includes the H-bond Network Filter, but requires that networks are at least 75% satisfied! See the puzzle comments for more details. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. This puzzle will remain open for two weeks.

1176: Revisiting Puzzle 124: PDZ Domain

This is a throwback puzzle to the early days of Foldit. This domain is a component of many proteins involved in cell signaling. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1175: Unsolved De-novo Freestyle 62

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1173: Revisiting Puzzle 117: Transport Mutant

This is a throwback puzzle to the early days of Foldit. This small protein participates in electron transfer reactions in the cell. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.