Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
-
Here is the next Mini-CASP target whose solved structure will be released soon. Mini-CASP 17 has close homologs that we can use as templates. There are 3 different templates you can choose from by clicking 'Show Alignment' from the actions tab. We will give you Rosetta@home predictions for this target next week. For players with fewer than 150 global points.
-
In order to bind the ligand in this puzzle, you'll need to make at least three hydrogen bonds to the end of the ligand that is buried in the protein. However, these hydrogen bonds need to be ideal - so that the angles between the atoms forming the bonds are within a particular range. The more ideal, the better. There is a condition in this puzzle that will show you where to form the hydrogen bonds, and if they are unideal, which angles are off. If you have hydrogen bonds with unideal angles it might be good to try mutations to form different bonds rather than fix up the unideal ones. The ligand is in a pretty good spot already so there are also some constraints to keep it from moving too far in or out of the protein. We're not even sure it's possible so we're very excited to see what solutions you come up with!
-
Here are more templates for Mini-CASP 14. Try using all 5 templates since this is your last chance; the native will be released very soon!
-
Here are more templates for Mini-CASP 14. Try using all 5 templates since this is your last chance; the native will be released very soon! For players with fewer than 15 global points.
-
Closed
since
about 16 years
ago
Here are more templates for Mini-CASP 14. Try using all 5 templates since this is your last chance; the native will be released very soon! For players with fewer than 150 global points.
-
We're sorry that we had to close Mini-CASP 16, but the native was released sooner than we had expected. To replace it, here are 3 templates to work with for Mini-CASP 14. The native for this target will also be released very soon, but hopefully not as fast as for puzzle 265.
-
We're sorry that we had to close Mini-CASP 16, but the native was released sooner than we had expected. To replace it, here are 3 templates to work with for Mini-CASP 14. The native for this target will also be released very soon, but hopefully not as fast as for puzzle 265. For players with fewer than 15 global points.
-
We're sorry that we had to close Mini-CASP 16, but the native was released sooner than we had expected. To replace it, here are 3 templates to work with for Mini-CASP 14. The native for this target will also be released very soon, but hopefully not as fast as for puzzle 265. For players with fewer than 150 global points.
-
This puzzle has two templates to choose from! You can choose "Show Alignment" from the Actions tab to use the new sequence alignment tool. See if you can find a better alignment than the starting one for this structure!
-
Our next Mini-CASP target, whose structure will be released very soon, has close homologs that we can use as templates. There are 3 different templates you can choose from by clicking 'Show Alignment' from the actions tab. NOTE: We might have to close this puzzle early if the native is released before friday. For players with fewer than 15 global points.