Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
-
Our next Quest to the Native is based on Mini-CASP 3, but starting from an extended chain. This might be more difficult than usual, but we would like to see if you are able to reach this recently released native structure when given a guide of it, with a freestyle starting structure. Only the buried sidechains will be shown on the native guide. For players with fewer than 15 global points.
-
Our next Quest to the Native is based on Mini-CASP 3, but starting from an extended chain. This might be more difficult than usual, but we would like to see if you are able to reach this recently released native structure when given a guide of it, with a freestyle starting structure. Only the buried sidechains will be shown on the native guide. For players with fewer than 150 global points.
-
This is the last chance for Mini-CASP 15. This multi-start puzzle has Rosetta's top 5 predictions for this unsolved structure, each time you reset the puzzle one of these 5 starts will be randomly chosen. All five Rosetta models are very similar to one another, but hopefully you will be able to find a solution that is even closer to the native than Rosetta.
-
This is the last chance for Mini-CASP 15. This multi-start puzzle has Rosetta's top 5 predictions for this unsolved structure, each time you reset the puzzle one of these 5 starts will be randomly chosen. All five Rosetta models are very similar to one another, but hopefully you will be able to find a solution that is even closer to the native than Rosetta. For players with fewer than 15 global points.
-
This is the last chance for Mini-CASP 15. This multi-start puzzle has Rosetta's top 5 predictions for this unsolved structure, each time you reset the puzzle one of these 5 starts will be randomly chosen. All five Rosetta models are very similar to one another, but hopefully you will be able to find a solution that is even closer to the native than Rosetta. For players with fewer than 150 global points.
-
Our next Quest to the Native is based on Mini-CASP 11, but starting from an extended chain. This might be more difficult than usual, but we would like to see if you are able to reach this recently released native structure when given a guide of it, with a freestyle starting structure. Only the buried sidechains will be shown on the native guide.
-
Our next Quest to the Native is based on Mini-CASP 11, but starting from an extended chain. This might be more difficult than usual, but we would like to see if you are able to reach this recently released native structure when given a guide of it, with a freestyle starting structure. Only the buried sidechains will be shown on the native guide. For players with fewer than 15 global points.
-
Our next Quest to the Native is based on Mini-CASP 11, but starting from an extended chain. This might be more difficult than usual, but we would like to see if you are able to reach this recently released native structure when given a guide of it, with a freestyle starting structure. Only the buried sidechains will be shown on the native guide. For players with fewer than 150 global points.
-
The last set of solutions for this series was promising, so we're interested to see what happens with this setup. The core has been changed to Alanine for you to mutate. The loops are still locked, but this time there is no inserting allowed! Constraints are holding the backbone near where it starts out, so focus on the sidechains.
-
Here's one more puzzle that has a protein attaching to a piece of DNA. Again, there are several mutatable segments on the protein near the DNA. We hope you can use them to get a better score!
