Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Inspired by Puzzle 174, we decided to let you go free with this freestyle design! This puzzle has 80 designable segments. See what you can come up with!
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We are trying to see if you can get to the native structure on this puzzle without any native guidance from the Foldit team, that is, without a native guide, without telling you which public solutions are promising, etc. It is a test of whether the Foldit community working together in All-Hands mode can come up with a native fold on a tricky starting problem. The initial solutions for all-hands are drawn from your solutions to Puzzle 138 (Rosetta Decoy 2), using an algorithm with no knowledge of the native structure.
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In this protein interface, several sidechains have been mutated to Alanine. Can you mutate them back to their original sidechains? Go to Note Mode for more information!
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This protein has been changed entirely to Alanine, but the core can be mutated. Can you design a better core?
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Xylanase is an enzyme which degrades linear polysaccharides into xylose thus breaking down cellulose. It is found in cellulose digesting bacteria. The degradation of cellulose holds much promise in the field of renewable energy sources. A greater understanding of this system might lead to the discovery new bio-fuels.
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We would like to see how everyone can improve this Rosetta Decoy in only 2 days! This puzzle has no <15 or <150 version.
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The core of this protein is designable. Can you design a high scoring core?
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We like you to take another stab at this! We hope it will be easier. Again it will expire in two days. Thank you!
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We would like to see how everyone can do on this puzzle in only 2 days! Good luck! This puzzle has no <15 or <150 version.
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The next in our Quest to the Native Series, which is a repost of 148: Rosetta Decoy 11. This puzzle includes a ghost of the native structure, which has a score of 10571.069. Only the buried sidechains will be shown on the native ghost.
