Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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We would like you to refine your solutions from miniCASP1 - All Hands. There are 13 different starting structures, each time you reset the puzzle one of these 13 starts will be randomly chosen. We are giving you a couple extra days to fold, so we hope you will try out each of the 13 starting points. For players with less than 15 global points.
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We would like you to refine your solutions from miniCASP1 - All Hands. There are 13 different starting structures, each time you reset the puzzle one of these 13 starts will be randomly chosen. We are giving you a couple extra days to fold, so we hope you will try out each of the 13 starting points. For players with less than 150 global points.
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Our first ligand competition puzzle! The problem: With the current backbone the protein can only touch half of the ligand. The goal: Rebuild and insert and delete backbone segments in combination with mutating amino acids to shelter the ligand. There are four editable regions so focus on those!
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This All Hands puzzle contains 10 different starting structures outputted by Rosetta@Home. Since we have no idea which one is the closest to the native fold, we hope you will try them all out!
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This is Rosetta@Home's top-ranked prediction for Mini-CASP target 2. We have no idea if it is correct or not, but hopefully you can improve it! This puzzle has no <15 or <150 version.
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This is another high-ranking Rosetta@Home's prediction for Mini-CASP target 2. We tried to pick a model that is different from Mini-CASP 2a to give you diverse starting points. This puzzle has no <15 or <150 version.
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This is another high-ranking Rosetta@Home's prediction for Mini-CASP target 2. We tried to pick a model that is different from Mini-CASP 2a/2b to give you diverse starting points. Hopefully by starting with one of these Rosetta decoys you can get close to the native solution! This puzzle has no <15 or <150 version.
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Similar to the previous More Core Design, the core of this protein is designable and Alanine. Focus on the core sidechains in this puzzle!
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The second Mini-CASP target is a de-novo (or ab-initio) target. This means that there is no solved structure that has a similar sequence that we can start our predictions from. This is exciting because template-free targets are rare (in CASP8 only 11 of the 128 targets were free-modeling targets) so we are lucky to be able to predict this. Since we have no idea where to even start, we are giving you an extended chain to see what you come up with. This might not be easy, because this protein has 102 residues. The secondary structure shown is just a prediction, so it might not be correct, feel free to modify it as well. We will release the lowest energy Rosetta@home predictions for this target as puzzles later this week. Until then, good luck freestyle folding!
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In this protein interface, a few sidechains on the smaller piece have been mutated to Alanine. Can you mutate them back to their original sidechains? Go to Note mode for more information!
