Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Here is a highly ranked Rosetta@home prediction for Mini-CASP target 4. We have no idea if it is correct or not, but hopefully you can improve it! This puzzle has no < 15 or < 150 version. NOTE: This puzzle will expire this Tuesday.
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The next in our Quest to the Native Series is a repost of 190: Mini-CASP 2c. This puzzle includes a ghost of the recently released native structure, which has a score of 10266. Mini-CASP 2c was a high-ranking Rosetta@Home prediction, which was very far from the native solution. The goal of this puzzle is to see if players can reach the native structure, when given a ghost of it, from such a distant starting structure. Only the buried sidechains will be shown on the native ghost. This puzzle is also an Exploration Puzzle, your score will not register unless you explore far from the starting puzzle.
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The next in our Quest to the Native Series is a repost of 190: Mini-CASP 2c. This puzzle includes a ghost of the recently released native structure, which has a score of 10266. Mini-CASP 2c was a high-ranking Rosetta@Home prediction, which was very far from the native solution. The goal of this puzzle is to see if players can reach the native structure, when given a ghost of it, from such a distant starting structure. Only the buried sidechains will be shown on the native ghost. This puzzle is also an Exploration Puzzle, your score will not register unless you explore far from the starting puzzle. For players with less than 15 global points.
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The next in our Quest to the Native Series is a repost of 190: Mini-CASP 2c. This puzzle includes a ghost of the recently released native structure, which has a score of 10266. Mini-CASP 2c was a high-ranking Rosetta@Home prediction, which was very far from the native solution. The goal of this puzzle is to see if players can reach the native structure, when given a ghost of it, from such a distant starting structure. Only the buried sidechains will be shown on the native ghost. This puzzle is also an Exploration Puzzle, your score will not register unless you explore far from the starting puzzle. For players with less than 150 global points.
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Here is a highly ranked Rosetta prediction for Mini-CASP target 3. We have no idea if it is correct or not, but hopefully you can improve it! This puzzle has no <15 or <150 version. NOTE: This puzzle has been extended to Monday Sept. 28th!
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The third Mini-CASP target is another de-novo (or ab-initio) target. This means that there is no solved structure that has a similar sequence that we can start our predictions from. This is exciting because template-free targets are rare (in CASP8 only 11 of the 128 targets were free-modeling targets) so we are lucky to be able to predict this. Since we have no idea where to even start, we are giving you an extended chain to see what you come up with. This might not be easy, so we will release Rosetta predictions for this target as puzzles early next week. Until then, good luck freestyle folding! As suggested in the feedback (http://fold.it/portal/node/986548#comment-4998) we will post the secondary structure prediction in the puzzle comments.
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We are launching a new puzzle type today! You can read more about it in the blog. This puzzle has a condition that must be met: you will need to explore from the starting structure a little bit before your score will register. You can show the starting structure by clicking on "Conditions" under your score, then "Show".
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We've got a slighly different setup this time, now the ligand isn't movable! The problem: With the current backbone the protein can only touch half of the ligand. The goal: Rebuild and insert and delete backbone segments in combination with mutating amino acids to shelter the ligand. There are four editable regions so focus on those!
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While we work on fixing the server, here is a structure that begins totally extended. There is no secondary structure prediction for this puzzle, so how close to the native can you get starting completely from scratch? Good luck folding and we apologize again for all the server problems.
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We would like you to refine your solutions from miniCASP1 - All Hands. There are 13 different starting structures, each time you reset the puzzle one of these 13 starts will be randomly chosen. We are giving you a couple extra days to fold, so we hope you will try out each of the 13 starting points.
