Foldit Puzzles

2104: Revisiting Puzzle 112: Bovine

This is a throwback puzzle to the early days of Foldit. This particular protein is known as ubiquitin, and plays a prominent role in the protein degradation pathway. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2103: Olivetolic Acid Ligand Binder Design: Round 5

Note: This puzzle was closed early due to a missing Neural Net Objective, and has been reposted as Puzzle 2103b. Players may load solutions from this puzzle into the reposted puzzle.

2103b: Olivetolic Acid Ligand Binder Design: Round 5

Note: This puzzle replaces Puzzle 2103, which was missing the Neural Net Objective. Players may load in solutions from the original Puzzle 2103.

2102: Symmetric Trimer Design with AlphaFold Predictions

Note: This puzzle will crash if a player uses the Cut tool. The Foldit team has tracked down the bug and will release a software update shortly. In the meantime, please avoid using the Cut tool on this puzzle!

2101: Revisiting Puzzle 111: Mouse

This is a throwback puzzle to the early days of Foldit. This protein is found in the nucleus of stem cells in mice, and is important for maintaining the pluripotency of the stem cell. The protein is modeled here as in a reduced environment, so no disulfide bonds are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2100: Electron Density Reconstruction 3

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

Design of the Month: January 2022

This sandbox puzzle features a protein binder design by an anonymous player sgeldhof in Puzzle 2078: CD47 Binder Design: Round 5. The binder has a complementary shape for hydrophobics on the target surface, and perfectly satisfies buried polars. For more, check out Foldit Lab Report #28 on YouTube! This sandbox puzzle is non-competitive and will not award any points.

2099: Symmetric Trimer Design with AlphaFold Predictions

Design a symmetric protein trimer, with 3 identical chains of 60 residues each! This puzzle enables AlphaFold predictions for the monomer subunit of your design, so you can upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your monomer subunit only (i.e. in the unbound state, in the absence of other symmetric copies). If you load this prediction, then Foldit will attempt to align the prediction with your solution. If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the monomer subunit interacts with symmetric copies.

2098: Revisiting Puzzle 110: Turkey

This is a throwback puzzle to the early days of Foldit. This is a portion of a troponin protein found in the skeletal muscle of turkeys. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2097: TGF Receptor Binder Design: Round 15

Design a protein that can bind to the TGF-beta receptor! This puzzle enables AlphaFold predictions for your designed binder. Once you've designed a binder for the target, upload your solution for AlphaFold using the AlphaFold prediction tool. AlphaFold will predict the structure of your binder chain only (i.e. in the unbound state, in the absence of the target). If you load this prediction, then Foldit will attempt to align the prediction with your solution (i.e. in the bound state, making an interface with the target). If you continue working off of the AlphaFold prediction, you may need to make adjustments at the interface where the binder interacts with the target.