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1540: Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
June 23, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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    1. Beta Folders
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  1. Avatar for stomjoh 21. stomjoh Lv 1 43 pts. 11,357
  2. Avatar for phi16 22. phi16 Lv 1 41 pts. 11,336
  3. Avatar for robgee 23. robgee Lv 1 39 pts. 11,313
  4. Avatar for Crossed Sticks 24. Crossed Sticks Lv 1 37 pts. 11,273
  5. Avatar for Anfinsen_slept_here 25. Anfinsen_slept_here Lv 1 36 pts. 11,267
  6. Avatar for Vinara 26. Vinara Lv 1 34 pts. 11,251
  7. Avatar for NinjaGreg 27. NinjaGreg Lv 1 32 pts. 11,242
  8. Avatar for MicElephant 28. MicElephant Lv 1 31 pts. 11,150
  9. Avatar for nicobul 29. nicobul Lv 1 29 pts. 11,140
  10. Avatar for Bautho 30. Bautho Lv 1 28 pts. 11,116

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85, at a cost of 32 points per residue. Players may use up to 105 residues in total.