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1540: Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
June 23, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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    1. Beta Folders
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  1. Avatar for alwen 31. alwen Lv 1 26 pts. 11,094
  2. Avatar for christioanchauvin 32. christioanchauvin Lv 1 25 pts. 11,047
  3. Avatar for georg137 33. georg137 Lv 1 24 pts. 10,992
  4. Avatar for Museka 34. Museka Lv 1 23 pts. 10,987
  5. Avatar for smilingone 35. smilingone Lv 1 22 pts. 10,984
  6. Avatar for WBarme1234 36. WBarme1234 Lv 1 20 pts. 10,971
  7. Avatar for Blipperman 37. Blipperman Lv 1 19 pts. 10,944
  8. Avatar for sciencewalker 38. sciencewalker Lv 1 18 pts. 10,883
  9. Avatar for drumpeter18yrs9yrs 39. drumpeter18yrs9yrs Lv 1 17 pts. 10,874
  10. Avatar for Merf 40. Merf Lv 1 16 pts. 10,803

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85, at a cost of 32 points per residue. Players may use up to 105 residues in total.