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1540: Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
June 23, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 11,993
  2. Avatar for Gargleblasters 2. Gargleblasters 74 pts. 11,909
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 54 pts. 11,885
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  6. Avatar for Contenders 6. Contenders 18 pts. 11,681
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  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 5 pts. 10,676
  10. Avatar for Team South Africa 10. Team South Africa 3 pts. 9,737
  1. Avatar for lconor 41. lconor Lv 1 16 pts. 10,753
  2. Avatar for InfoManiac742 42. InfoManiac742 Lv 1 15 pts. 10,749
  3. Avatar for rezaefar 43. rezaefar Lv 1 14 pts. 10,700
  4. Avatar for JasperD 44. JasperD Lv 1 13 pts. 10,676
  5. Avatar for dbuske 45. dbuske Lv 1 12 pts. 10,652
  6. Avatar for Seagat2011 46. Seagat2011 Lv 1 12 pts. 10,589
  7. Avatar for joremen 47. joremen Lv 1 11 pts. 10,573
  8. Avatar for Deleted player 48. Deleted player pts. 10,438
  9. Avatar for yoyoparis 49. yoyoparis Lv 1 10 pts. 10,412
  10. Avatar for silent gene 50. silent gene Lv 1 9 pts. 10,375

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85, at a cost of 32 points per residue. Players may use up to 105 residues in total.