Placeholder image of a protein
Icon representing a puzzle

1540: Large Monomer Design

Closed since over 7 years ago

Intermediate Overall Design

Summary

Created
June 23, 2018
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 11,993
  2. Avatar for Gargleblasters 2. Gargleblasters 74 pts. 11,909
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 54 pts. 11,885
  4. Avatar for Void Crushers 4. Void Crushers 38 pts. 11,762
  5. Avatar for Go Science 5. Go Science 27 pts. 11,714
  6. Avatar for Contenders 6. Contenders 18 pts. 11,681
  7. Avatar for Marvin's bunch 7. Marvin's bunch 12 pts. 11,459
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 8 pts. 11,443
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 5 pts. 10,676
  10. Avatar for Team South Africa 10. Team South Africa 3 pts. 9,737
  1. Avatar for mitarcher 61. mitarcher Lv 1 5 pts. 9,821
  2. Avatar for Superphosphate 62. Superphosphate Lv 1 4 pts. 9,786
  3. Avatar for doctaven 63. doctaven Lv 1 4 pts. 9,737
  4. Avatar for GaryForbis 64. GaryForbis Lv 1 4 pts. 9,646
  5. Avatar for pfirth 65. pfirth Lv 1 4 pts. 9,603
  6. Avatar for Flagg65a 66. Flagg65a Lv 1 3 pts. 9,552
  7. Avatar for SouperGenious 67. SouperGenious Lv 1 3 pts. 9,541
  8. Avatar for toshiue 68. toshiue Lv 1 3 pts. 9,450
  9. Avatar for spritz1992 69. spritz1992 Lv 1 3 pts. 9,394
  10. Avatar for gdnskye 70. gdnskye Lv 1 2 pts. 9,225

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

SS Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets. Penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85, at a cost of 32 points per residue. Players may use up to 105 residues in total.