Foldit Puzzles

1659b: Integrin Antagonist Binder Design

Help design a protein binder for cancer therapy!

1658: Symmetric Dimer Design: 80 Residues

This symmetric design puzzle has C2 symmetry, with two symmetric chains. There is no H-bond Network Objective in this puzzle, so the interface can be completely nonpolar (orange sidechains). No more than 50% of residues may form helices, and all loops must match one of the Ideal Loop Building Blocks found in the Blueprint tool. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1657: Unsolved De-novo Freestyle 150

The structure of this protein is still unknown. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1656: Revisiting Puzzle 117: Transport Mutant

This is a throwback puzzle to the early days of Foldit. This small protein participates in electron transfer reactions in the cell. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1655: Symmetric Tetramer Design: 65 Residues

Note: This puzzle was closed early due to a faulty Objective, and reposted as Puzzle 1655b. Players may load their current work into the reposted puzzle.

Puzzle 1655b: Symmetric Tetramer Design: 65 Residues

Note: This puzzle replaces Puzzle 1655, which was posted with a faulty Objective. Players may load in solutions from the original Puzzle 1655.

1653: Y1 Receptor virtual screening

THIS IS A MULTISTART PUZZLE - Click "RESET PUZZLE" to cycle through each of six starting structures.

1654: Revisiting Puzzle 115: Exocyst

This is a throwback puzzle to the early days of Foldit. This protein is involved in the process of exocytosis, transporting proteins to the cell membrane or extracellular areas. The protein is modeled here in reduced form, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1652: Unsolved De-novo Freestyle 149: Symmetric Dimer

This is a follow-up to Puzzle 1649: De-novo Freestyle 149, now with C2 symmetry. This protein was originally designed by a Foldit player as a symmetric dimer. In Puzzle 1649, we challenged the Foldit community to try and predict how the design might fold as a single, monomeric chain. Now we want to see if Foldit players can predict how the original protein was designed to fold and bind to itself with C2 symmetry. Players may load in solutions from Puzzle 1649. Secondary structure predictions (from PSIPRED) are marked on the starting structure, and provide clues about where the protein might form helices and sheets!

1651: Revisiting Puzzle 114: Black Mamba

This is a throwback puzzle to the early days of Foldit. This toxin is produced in the intestines of the African black mamba. The protein contains ten cysteines that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.