Foldit Puzzles

1576: Large Monomer Design

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1575: Revisiting Puzzle 80: Calcium Channel Blocker

This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1572b: Quick Multi-Start Density Repost

This is a repost of Puzzle 1572, which was unable to load solutions from the previous Puzzle 1554. Players may now load solutions from Puzzle 1554, as well as any work in the original Puzzle 1572. NOTE: If you did not manually save a solution in 1554 or 1572, you can go back to either puzzle, manually save it, and the solution should appear in your manual saves for this puzzle.

1574: Extra Small Monomer Design

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1572: Cryo-EM Multi-Start with Density

This is a repost of Puzzle 1554, now with electron density! This protein is part of a large protein complex with multiple subunits, which has recently been the target of some cryo-electron microscopy (cryo-EM) experiments. Load in your Puzzle 1554 solutions and see if you can improve them to fit the density! We are giving you the same 5 server predictions as starting points. NOTE: If you did not manually save a solution in Puzzle 1554, you can go back to 1554, manually save it, and the solution should appear in your manual saves for this puzzle.

1569: Design Partition Tournament: Phase One

This the Phase One design puzzle for the Protein Design Partition Tournament! Players have two weeks to craft their best protein design, which will have to defend itself in Phase Two of the tournament. For players who do not wish to participate in the tournament, this puzzle will also behave like a normal Foldit puzzle, and points will be awarded to top-ranking players and teams as usual. Players may use 70-100 residues, at a cost of 32 points per residue; and designs with more than 10% helices will be penalized 10 points per extra residue in a helix.

1571: Revisiting Puzzle 79: Pheromone

This is a throwback puzzle to the early days of Foldit. This pheromone protein is secreted by the protist E. raikovi to initiate conjugation, the exchange of genetic material between two cells. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1570: Symmetric Trimer Design: Hydrogen Bond Networks

This symmetric design puzzle has C3 symmetry, with three symmetric chains. The H-bond Network Filter encourages players to bury satisfied H-bond networks at the interface between the three chains. We've doubled the H-bond network bonus, but we'd like players to focus on building networks deep in the core of the protein complex. There a couple other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1568: Revisiting Puzzle 77: Copper Chaperone

This is a throwback puzzle to the early days of Foldit. This protein binds copper ions so that they may be transported safely to the cell compartments and enzymes that require them. The protein is modeled here in the reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.