Foldit Puzzles

1587: Partition Puzzle: Galaxie

This is a repost of Partition Puzzle (B): Galaxie, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by Galaxie. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 16.

1585: Partition Puzzle: matosfran

This is a repost of Partition Puzzle (B): matosfran, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by matosfran. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 15.

1584: Partition Puzzle: actiasluna

This is a repost of Partition Puzzle (B): actiasluna, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by actiasluna. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 14.

1583: Partition Puzzle: LociOiling

This is a repost of Partition Puzzle (B): LociOiling, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by LociOiling. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 13.

1581: Small Monomer Design

This puzzle challenges players to design a single-chain protein with 65-75 residues. The starting structure has 65 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for Objective details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1582: Partition Puzzle: wisky

This is a repost of Partition Puzzle (B): wisky, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by wisky. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 9.

1579: 221-residue Cryo-EM Multi-Start Puzzle

This bigger protein is another part of the same protein complex with multiple subunits from Puzzle 1554, which has been the target of cryo-EM experiments. We are giving you 5 different server predictions as starting points. Reset the puzzle to cycle through the different starting models.

1580: Partition Puzzle: fiendish_ghoul

This is a repost of Partition Puzzle (B): fiendish_ghoul, which is part of the Protein Design Partition Tournament. Unlike the previous puzzle, this repost is for points, and will count in the Overall and Prediction categories. The starting structure is a protein designed by fiendish_ghoul. We are challenging Foldit players to refold the designed protein, to try to find high-scoring decoy structures. This puzzle includes an RMSD Objective, which requires all solutions to be different from the starting structure with an RMSD of at least 2.5 Å. Players that have participated in the original Partition Puzzle will be able to load solutions into this puzzle. Note that this puzzle will only be available for a short time, and will expire on October 5.

1578: Medium Monomer Design

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1577: Revisiting Puzzle 81: Calcium Ion Binding Protein

This is a throwback puzzle to the early days of Foldit. This protein, which inhibits muscle contraction in the absence of calcium ions, changes conformation in the presence of calcium to allow muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.