Foldit Puzzles

1595: Aflatoxin Challenge: Round 12

Note: Due to a bug in solution sharing and loading, this puzzle is worth zero points and will close early. We encourage players to play replacement puzzle Puzzle 1597 instead, although we will still analyze the solutions from this puzzle if players wish to keep working on their designs. Unfortunately players may not load solutions from this puzzle into the replacement Puzzle 1597.

1593: Revisiting Puzzle 84: Giant Anemone

This is a throwback puzzle to the early days of Foldit. This toxin, which is released by the sea anemone A. xanthogrammica, disrupts normal contraction of cardiac muscle in potential predators, and furthermore serves as a pheromone to signal danger to nearby anemones. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1590b: Aflatoxin Challenge: Round 11

Note: This puzzle was closed early, due to some continuing scoring issues, and reposted as Puzzle 1590c.

1590c: Aflatoxin Challenge: Round 11

Note: This puzzle replaces Puzzle 1590b, which had some intermittent scoring problems. Players may load in solutions saved from Puzzle 1590b.

1588: 221-residue Cryo-EM Multi-Start with Density

This is a repost of Puzzle 1579, now with electron density! Load in your Puzzle 1579 solutions and see if you can improve them to fit the density! We are giving you the same 5 server predictions as starting points, and over TWO WEEKS to work on this difficult target. Read the blogpost for more details.

1592: Symmetric Dimer Design: Limited Interface

Note: Due to exceptional performance issues, this puzzle has been made worth zero points. Players should not feel compelled to play this puzzle to remain competitive on the leaderboards. However, if you are able to play this puzzle without issue, we'll still analyze any solutions.

1591: Revisiting Puzzle 83: Cardiotoxin

This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Chinese cobra N. atra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1589: Extra Small Monomer Design

This puzzle challenges players to design a single-chain protein with 60-65 residues. The starting structure has 60 residues, but more can be inserted at a cost of 32 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1586: Revisiting Puzzle 82: Cytotoxin

This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Mozambique spitting cobra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues, which oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.