Foldit Puzzles

1094: De-novo Freestyle 51: Hand-folding Round

In this de-novo freestyle puzzle, only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be reposted with LUA scripts and sharing enabled. The PSIPRED secondary structure predictions are provided on the starting model.

1093: 75 Residue Monomer Design: Best Fragments

This puzzle uses a more stringent fragment filter than previous design puzzles. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1092: Revisiting Puzzle 74: Platypus Venom

This is a throwback puzzle to the early days of Foldit. This small peptide was discovered in platypus venom—a rare instance of mammalian-produced venom, although this peptide appears similar to more widespread antimicrobials. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1091: Blind Electron Density 12: C-terminus

Scientists have had difficulty solving the structure of this bacterial enzyme, which participates in the synthesis of certain antimicrobial compounds. Players folded the N-terminal half of the protein previously in Puzzle 1088; in this puzzle we'll focus on the C-terminal half of the protein. The starting solution is based on the structure of a homologous protein. See if you can find a solution that better fits the density!

1090: 80 Residue Symmetric Dimer Design

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1089: Revisiting Puzzle 73: Polycystein

This is a throwback puzzle to the early days of Foldit. This domain is a component of a large glycoprotein in humans, which has been linked to autosomal dominant polycystic kidney disease. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1088: Blind Electron Density 12: N-terminus

Scientists have had difficulty solving the structure of this bacterial enzyme, which participates in the synthesis of certain antimicrobial compounds. The full protein is too large to model in Foldit, so we'll approach it in two separate puzzles; in this puzzle we'll focus on the N-terminal half of the protein. The starting solution is based on the structure of a homologous protein. See if you can find a solution that better fits the density!

1087: Hydrogen Bond Network Filter

Note: This puzzle has been taken down and will be re-posted at a later date.

1086: Revisiting Puzzle 72: Citric Acid Cycle

This is a throwback puzzle to the early days of Foldit. This short protein is a component of the α-ketoglutarate dehydrogenase complex, which is best known for its role in the citric acid cycle. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1085: Player-Solution Redesign

See if you can improve this Foldit player-designed protein! This protein was a top-scoring solution by karstenw for Puzzle 1065. Scientists here at the Baker Lab see a lot of potential in this initial design, but want to see if other Foldit players can improve upon it. Note that this puzzle includes an Exploration Filter—changing the shape of the protein too much will disqualify your solution!