Foldit Puzzles

2558: Revisiting Puzzle 89: Cow Eye

This is a throwback puzzle to the early days of Foldit. This small domain is part of a larger protein found at high concentrations of the lens of the eye; historically, this protein was purified from the eyes of B. taurus for research. The protein is modeled here in reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2556: KCNT1 Round 5

KCNT1 is a sodium-activated potassium channel that critically influences how neurons fire. When functioning normally, KCNT1 helps maintain a healthy balance of electrical signaling in the brain. However, mutations in the KCNT1 gene can lead to a range of severe epileptic conditions such as Malignant Migrating Partial Seizures of Infancy (MMPSI).

2554: Refine Density Reconstruction 18

This is a protein we've given before in puzzle 2427, which was Reconstruction Puzzle 81, but now we have the Refine Density tool available to make folds even better! There's two chains here of the same thing, but both are missing a few residues that are slightly different.

2555: Revisiting Puzzle 88: Monocyte

This is a throwback puzzle to the early days of Foldit. This protein is secreted at the site of inflammation, recruiting monocytes and T cells to help fight an infection. This protein contains four cysteine residues that oxidize to form two disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2551: Refine Density Reconstruction 17

This is a protein we've given before in puzzle 2296, which was Reconstruction Puzzle 38, but now we have the Refine Density tool available to make folds even better!

2553: KCNT1 Round 4

KCNT1 is a sodium-activated potassium channel that critically influences how neurons fire. When functioning normally, KCNT1 helps maintain a healthy balance of electrical signaling in the brain. However, mutations in the KCNT1 gene can lead to a range of severe epileptic conditions such as Malignant Migrating Partial Seizures of Infancy (MMPSI).

2552: Revisiting Puzzle 87: Zinc Binding Protein

This is a throwback puzzle to the early days of Foldit. This small peptide is part of a larger protein that helps to regulate cell division, and is very important in early embryonic development. The protein is modeled here as in a reduced environment, so no disulfide bonds are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2550: KCNT1 Round 3

KCNT1 is a sodium-activated potassium channel that critically influences how neurons fire. When functioning normally, KCNT1 helps maintain a healthy balance of electrical signaling in the brain. However, mutations in the KCNT1 gene can lead to a range of severe epileptic conditions such as Malignant Migrating Partial Seizures of Infancy (MMPSI).

2548: Refine Density Reconstruction 17

This is a protein we've given before in puzzle 2261, which was Reconstruction Puzzle 26, but now we have the Refine Density tool available to make folds even better! his puzzle has a couple copies of two proteins as well as peptides bound.

2549: Revisiting Puzzle 86: Nematode

This is a throwback puzzle to the early days of Foldit. This protein, isolated from the hookworm A. caninum, is an extremely potent anticoagulant. This protein contains ten cysteine residues that oxidize to form five disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.