Foldit Puzzles

2538: Refine Density Reconstruction 15

This is a protein we've given before in puzzle 2234, which was Reconstruction Puzzle 18, but now we have the Refine Density tool available to make folds even better!

2537: Revisiting Puzzle 82: Cytotoxin

This is a throwback puzzle to the early days of Foldit. This toxin, produced by the Mozambique spitting cobra, induces contracture in skeletal and cardiac muscle. This protein contains eight cysteine residues, which oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2536: KCNQ1 VSD Round 9

KCNQ1 is a critical gene that helps regulate the heart's rhythm by encoding the Kv7.1 potassium ion channel. Mutations in KCNQ1 can cause congenital long QT syndrome (LQTS), an inherited heart condition that increases the risk of sudden cardiac death, especially in young people. While previous puzzles have focused on one domain of KCNQ1, in this challenge we're taking a similar but different approach by targeting the Voltage Sensing Domain (VSD) of KCNQ1.

2535: Refine Density Reconstruction 14

This is a protein we've given before in puzzle 2312, which was Reconstruction Puzzle 43, but now we have the Refine Density tool available to make folds even better!

2534: Revisiting Puzzle 81: Calcium Ion Binding Protein

This is a throwback puzzle to the early days of Foldit. This protein, which inhibits muscle contraction in the absence of calcium ions, changes conformation in the presence of calcium to allow muscle contraction. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2533: KCNQ1 VSD Round 8

KCNQ1 is a critical gene that helps regulate the heart's rhythm by encoding the Kv7.1 potassium ion channel. Mutations in KCNQ1 can cause congenital long QT syndrome (LQTS), an inherited heart condition that increases the risk of sudden cardiac death, especially in young people. While previous puzzles have focused on one domain of KCNQ1, in this challenge we're taking a similar but different approach by targeting the Voltage Sensing Domain (VSD) of KCNQ1.

2532: Refine Density Reconstruction 13

This is a protein we've given before in puzzle 2415, which was Reconstruction Puzzle 77, but now we have the Refine Density tool available to make folds even better! And yes, this protein looks kind of funny on its own, in reality there is symmetry here and so there is more actual packing in reality.

2531: Revisiting Puzzle 80: Calcium Channel Blocker

This is a throwback puzzle to the early days of Foldit. This toxin is found in green mamba venom, and blocks the flow of calcium ions that normally depolarize the muscle cell to induce muscle contraction. This protein contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2530: KCNQ1 VSD Round 7

KCNQ1 is a critical gene that helps regulate the heart's rhythm by encoding the Kv7.1 potassium ion channel. Mutations in KCNQ1 can cause congenital long QT syndrome (LQTS), an inherited heart condition that increases the risk of sudden cardiac death, especially in young people. While previous puzzles have focused on one domain of KCNQ1, in this challenge we're taking a similar but different approach by targeting the Voltage Sensing Domain (VSD) of KCNQ1.

2529: Refine Density Reconstruction 12

This is a protein we've given before in puzzle 2388, which was Reconstruction Puzzle 68, but now we have the Refine Density tool available to make folds even better!