Foldit Puzzles

2458: CASP16 Ligand Puzzle L4000

Use the Ligand Queue (default hotkey 7) to explore how different ligand bind to the protein.

2457: Refine Density Reconstruction 1

This is a protein we've given before in puzzle 2100, which was Reconstruction Puzzle 3, but now we have the Refine Density tool available to make folds even better! Learn about the new tool here: https://fold.it/forum/blog/new-tool-refine-density. We'll also have a workshop on the tool on Youtube (https://www.youtube.com/watch?v=MdIXuGJkS0A) at 16:00 UTC on this Saturday May 18th.

2456: Revisiting Puzzle 54: Human Fyn

This is a throwback puzzle to the early days of Foldit. This kinase protein is part of a human signaling pathway that controls cell growth. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2455: CASP16 Ligand Puzzle L2000

Use the Ligand Queue (default hotkey 7) to explore how different ligand bind to the protein.

2454: Electron Density Reconstruction 90

The structure of this protein-DNA complex has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. You may notice that there’s a base pair in here that doesn’t look normal; it’s a Hoogsteen base pair (as opposed to Watson-Crick). Later on, we’ll ask you to play another version of this puzzle where it’s been put in as Watson-Crick instead of Hoogsteen as we’d like to see which works better. Also, a useful note from Bletchley Park for working with DNA: DNA sidechains can be turned relative to their blue arms with bands.

2453: Revisiting Puzzle 52: Bacteria Energy

This is a throwback puzzle to the early days of Foldit. This protein is part of a metabolic pathway used by bacteria to harvest energy from sugars. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with puzzles that are still scientifically relevant.

2452: CASP16 Ligand Puzzle L1000

Use the Ligand Queue (default hotkey 7) to explore how different ligand bind to the protein.

2451: Electron Density Reconstruction 89

The structure of this protein-DNA complex has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

2450: Revisiting Puzzle 786

This is a repost of a De-novo Freestyle puzzle we ran in October of 2013. Your solutions for this puzzle will help us evaluate some features of the recent Foldit updates. Players will NOT be able to load in solutions from Puzzle 786.

2449: Revisiting CCHFV Round 4

The Crimean-Congo Hemorrhagic Fever (CCHF) is a life-threatening zoonotic disease caused by a tick-borne virus. Recent research has revealed the significant role of the viral-encoded Ovarian Tumor (OTU) deubiquitinase in the CCHFV replication process. Based on the most promising compounds, this puzzle will focus on getting an inhibitor for this protein. As the CCHFV-OTU protease interacts with another protein (ubiquitin), the interaction surface is quite large and superficial, making it a challenging binding pocket. For this round we will be focusing on the upper binding pocket. For more details check out the Crimean-Congo Hemorrhagic Fever blog post.