Foldit Puzzles

2468: Revisiting Puzzle 59: TCR Binding Protein

This is a throwback puzzle to the early days of Foldit. This small, intracellular domain binds to the CD2 T cell receptor (TCR), and plays a critical role in T cell activation during the immune response. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2467: CASP16 Ligand Puzzle L3000 Round 2

Use the Reaction Design Panel (no default hotkey) and the Compound Library (default hotkey H) to explore how different ligands bind to the protein.

2466: Electron Density Reconstruction 92

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. It's got two chains that are the same. Of note, this protein may look familiar, as it's a protein commonly used by crystallographers to test methods, and so it's been solved many times, but some of these could use re-examination. For this first round of this puzzle, we won't have the Refine Density tool active.

2465: Revisiting Puzzle 58: Insulin Mutant

This is a throwback puzzle to the early days of Foldit. These are the two chains of a bio-engineered variant of human insulin, which contains six cysteine residues that oxidize to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.

2464: CASP16 Ligand Puzzle L1000 Round 2

Use the Ligand Queue (default hotkey 7) to explore how different ligand bind to the protein.

2463: Electron Density Reconstruction 91

We're going to take a break for a week from puzzles with the Refine Density tool and do an old-fashioned Reconstruction puzzle. The structure of this protein-DNA complex has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. Previously, we had a puzzle in which there was a Hoogsteen base pair in this structure, but now it has a Watson-Crick base pair instead. Also, a useful note from Bletchley Park for working with DNA: DNA sidechains can be turned relative to their blue arms with bands.

2462: Revisiting Puzzle 57: Beta-Neurotoxin

This is a throwback puzzle to the early days of Foldit. This scorpion toxin is similar to the one from Puzzle 55, and binds to voltage-gated ion channels of insects. The protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2461: CASP16 Ligand Puzzle L3000

Use the Ligand Queue (default hotkey 7) and the Compound Library (default hotkey H) to explore how different ligand bind to the protein.

2460: Refine Density Reconstruction 2

This is a protein we've given before in puzzle 2258, which was Reconstruction Puzzle 25, but now we have the Refine Density tool available to make folds even better! Learn about the new tool here: https://fold.it/forum/blog/new-tool-refine-density.

2459: Revisiting Puzzle 55: Scorpion Toxin

This is a throwback puzzle to the early days of Foldit. This scorpion toxin binds to voltage-gated ion channels in insects, resulting in full-body paralysis. The protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.