Foldit Puzzles

2428: Y4R: Round 7

Neuropeptide Y receptor subtype 4 (Y4R) is a key player in the fight against obesity. Y4R is a type of receptor found in the body, particularly in the brain, that helps control appetite and manage energy. It's part of a larger family known as the NPY receptors, which includes four subtypes: Y1R, Y2R, Y4R, and Y5R. Y4R is especially important because it plays a big role in regulating hunger and weight. Scientists have recently discovered that Y4R is crucial for reducing appetite and helping with weight loss in both humans and mice. They've found some special molecules, called allosteric modulators, that can interact with Y4R in a unique way. Unlike typical drugs that bind directly to the main part of a receptor (called the orthosteric site), allosteric modulators attach to a different part (the allosteric site). This is like using a backdoor to influence how the receptor works. By targeting these backdoor sites, we can more precisely control the receptor's activity without interfering with other similar receptors. This means we can create safer and more specific drugs. In this puzzle, your challenge is to design small molecules that can cleverly and safely interact with Y4R's backdoor sites. These molecules could play a crucial role in creating new treatments for obesity. This puzzle is an opportunity for you to dive into the world of drug discovery and make a difference in the battle against obesity. Your creativity and problem-solving skills can help us find new ways to target Y4R and improve health!

2427:Electron Density Reconstruction 81

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. There's two chains here of the same thing, but both are missing a few residues that are slightly different.

2426: Revisiting Puzzle 144: Rosetta Decoy 8

This is a throwback puzzle to the early days of Foldit. The function of this thermophilic protein is unknown, but it is unusual among intracellular proteins in that the native structure includes disulfide bonds. This protein contains six cysteine residues that are oxidized to form three disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2425: Y4R: Round 6

Neuropeptide Y receptor subtype 4 (Y4R) is a key player in the fight against obesity. Y4R is a type of receptor found in the body, particularly in the brain, that helps control appetite and manage energy. It's part of a larger family known as the NPY receptors, which includes four subtypes: Y1R, Y2R, Y4R, and Y5R. Y4R is especially important because it plays a big role in regulating hunger and weight. Scientists have recently discovered that Y4R is crucial for reducing appetite and helping with weight loss in both humans and mice. They've found some special molecules, called allosteric modulators, that can interact with Y4R in a unique way. Unlike typical drugs that bind directly to the main part of a receptor (called the orthosteric site), allosteric modulators attach to a different part (the allosteric site). This is like using a backdoor to influence how the receptor works. By targeting these backdoor sites, we can more precisely control the receptor's activity without interfering with other similar receptors. This means we can create safer and more specific drugs. In this puzzle, your challenge is to design small molecules that can cleverly and safely interact with Y4R's backdoor sites. These molecules could play a crucial role in creating new treatments for obesity. This puzzle is an opportunity for you to dive into the world of drug discovery and make a difference in the battle against obesity. Your creativity and problem-solving skills can help us find new ways to target Y4R and improve health!

2424: Electron Density Reconstruction 80

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. There's two copies of two chains each in this structure, two of which are quite short.

2423: Revisiting Puzzle 143: Rosetta Decoy 7

This is a throwback puzzle to the early days of Foldit. This enzyme helps to regenerate a cofactor that is necessary for nucleic acid synthesis; the starting structure is a model produced by Rosetta. This protein contains only one cysteine, so no disulfide bonds are expected. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2422: Y4R: Round 5

Neuropeptide Y receptor subtype 4 (Y4R) is a key player in the fight against obesity. Y4R is a type of receptor found in the body, particularly in the brain, that helps control appetite and manage energy. It's part of a larger family known as the NPY receptors, which includes four subtypes: Y1R, Y2R, Y4R, and Y5R. Y4R is especially important because it plays a big role in regulating hunger and weight. Scientists have recently discovered that Y4R is crucial for reducing appetite and helping with weight loss in both humans and mice. They've found some special molecules, called allosteric modulators, that can interact with Y4R in a unique way. Unlike typical drugs that bind directly to the main part of a receptor (called the orthosteric site), allosteric modulators attach to a different part (the allosteric site). This is like using a backdoor to influence how the receptor works. By targeting these backdoor sites, we can more precisely control the receptor's activity without interfering with other similar receptors. This means we can create safer and more specific drugs. In this puzzle, your challenge is to design small molecules that can cleverly and safely interact with Y4R's backdoor sites. These molecules could play a crucial role in creating new treatments for obesity. This puzzle is an opportunity for you to dive into the world of drug discovery and make a difference in the battle against obesity. Your creativity and problem-solving skills can help us find new ways to target Y4R and improve health!

2421: Electron Density Reconstruction 79

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. This case has both a monomer protein and also a bit of DNA as well, so some recipes might struggle with the DNA portion.

2420: Revisiting Puzzle 142: Rosetta Decoy 6

This is a throwback puzzle to the early days of Foldit. This protein was evolved in vitro to bind testosterone; the starting structure is a model produced by Rosetta. This protein contains two cysteine residues, which oxidize to form a single disulfide bond. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been and to provide newer players with problems that are still scientifically relevant.

2419: Y4R: Round 4

Neuropeptide Y receptor subtype 4 (Y4R) is a key player in the fight against obesity. Y4R is a type of receptor found in the body, particularly in the brain, that helps control appetite and manage energy. It's part of a larger family known as the NPY receptors, which includes four subtypes: Y1R, Y2R, Y4R, and Y5R. Y4R is especially important because it plays a big role in regulating hunger and weight. Scientists have recently discovered that Y4R is crucial for reducing appetite and helping with weight loss in both humans and mice. They've found some special molecules, called allosteric modulators, that can interact with Y4R in a unique way. Unlike typical drugs that bind directly to the main part of a receptor (called the orthosteric site), allosteric modulators attach to a different part (the allosteric site). This is like using a backdoor to influence how the receptor works. By targeting these backdoor sites, we can more precisely control the receptor's activity without interfering with other similar receptors. This means we can create safer and more specific drugs. In this puzzle, your challenge is to design small molecules that can cleverly and safely interact with Y4R's backdoor sites. These molecules could play a crucial role in creating new treatments for obesity. This puzzle is an opportunity for you to dive into the world of drug discovery and make a difference in the battle against obesity. Your creativity and problem-solving skills can help us find new ways to target Y4R and improve health!