Foldit Puzzles

2268: Electron Density Reconstruction 28

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. There are two chains in this puzzle that have the same sequence.

Design of the Month: February 2023

This sandbox puzzle features a FMN ligand binder design by blazegeek from Puzzle 2248. This design does a great job of burying hydrophobic atoms, with the hydrophobic end of of the FMN ligand target buried in a tightly packed hydrophobic pocket. Since the polar end of FMN is exposed to solvent, this binder does not make many hydrogen bonds to the ligand. This is okay for binding strength, but could hurt the binding specificity, with nothing to stop binding to other hydrophobic ligands. For more, check out the latest Foldit Lab Report on YouTube! This sandbox puzzle is non-competitive and will not award any points.

2267: SARS-CoV-2 Nsp3 CACHE Challenge 3: Round 2

Compete in a challenge to design a drug targeting the SARS-CoV-2 Nsp3 macrodomain. Use the small molecule design tools and the compound library panel to find library compounds which bind to the active site of the enzyme. -- Only compounds which come from the Compound Library panel and get the Compound Library objective bonus will be experimentally tested.

2266: Electron Density Reconstruction 27

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model.

2265: Revisiting Puzzle 68: Bos Taurus

This is a throwback puzzle to the early days of Foldit. This cow protein, found in epithelial cells of the intestine, binds calcium as it moves from the digestive tract into the blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2264: SARS-CoV-2 Nsp3 CACHE Challenge 3: Round 1

Compete in a challenge to design a drug targeting the SARS-CoV-2 Nsp3 macrodomain. Use the small molecule design tools and the compound library panel to find library compounds which bind to the active site of the enzyme. -- Only compounds which come from the Compound Library panel and get the Compound Library objective bonus will be experimentally tested.

2263: Revisiting Puzzle 67: Integrase

This is a throwback puzzle to the early days of Foldit. This DNA-binding domain is part of a bacterial integrase protein, which facilitates the insertion of new DNA into the bacterial chromosome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2262: FMN Ligand Binder Design: Round 7

Design a binding pocket for the FMN ligand! The Neural Net Objective awards a 2000 pt. bonus for AlphaFold predictions with both high confidence and high similarity to the current solution. After an AlphaFold prediction is complete, load the original or predicted structure from the AlphaFold panel to receive the bonus. You can continue to work on this solution, but the bonus will disappear if the similarity drops. Note that the table in the AlphaFold panel only displays the similarity of the original solution; the true similarity of your current solution is recalculated by the Neural Net Objective as you change its structure.

2261: Electron Density Reconstruction 26

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. This puzzle has a couple copies of two proteins as well as peptides bound, so it will be a bit different than usual.

2260: Revisiting Puzzle 66: Cytochrome

This is a throwback puzzle to the early days of Foldit. This protein helps to transfer electrons between substrates in bacteria. The protein is modeled here in reducing conditions, and no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.