Foldit Puzzles

2508: Refine Density Reconstruction 6

This is a protein we've given before in puzzle 2170, which was Reconstruction Puzzle 10, but now we have the Refine Density tool available to make folds even better! Learn about the new tool here: https://fold.it/forum/blog/new-tool-refine-density. This one won't allow loading solutions from that puzzle.

2507: CASP16 Ligand Puzzle L5000: Round 2

CASP organizers updated the ligand information for target L5001 that we previously had a puzzle for. Does having a more specific ligand help?

2506: KCNQ1 Round 11

KCNQ1 is a critical gene that helps regulate the heart's rhythm by encoding the Kv7.1 potassium ion channel. Mutations in KCNQ1 can cause congenital long QT syndrome (LQTS), an inherited heart condition that increases the risk of sudden cardiac death, especially in young people. In this puzzle, your challenge is to design a new activator for KCNQ1 that can restore function in variants linked to LQTS. For this puzzle we're going to switch up the task just a little. Now we want to target the Voltage Sensing Domain (VSD) of KCNQ1. It has been found that mutations to the VSD affect how effectively a protein is transported from its site of synthesis to the plasma membrane also known as trafficking. See blog post for more details, but note that we are looking at a different target site for KCNQ1 for this puzzle.

2504: Refine Density Reconstruction 5

This is a protein we've given before in puzzle 2197, which was Reconstruction Puzzle 12, but now we have the Refine Density tool available to make folds even better! Learn about the new tool here: https://fold.it/forum/blog/new-tool-refine-density. This one won't allow loading solutions from that puzzle.

2505: Revisiting Puzzle 71: Crystallin

This is a throwback puzzle to the early days of Foldit. This protein is found in high concentrations in the lens of the eye. Among its other functions, it is responsible for the high refractive index (and resulting optical properties) of the lens. The protein is modeled here in reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2503: KCNQ1 Round 10

KCNQ1 is a critical gene that helps regulate the heart's rhythm by encoding the Kv7.1 potassium ion channel. Mutations in KCNQ1 can cause congenital long QT syndrome (LQTS), an inherited heart condition that increases the risk of sudden cardiac death, especially in young people. In this puzzle, your challenge is to design a new activator for KCNQ1 that can restore function in variants linked to LQTS. For this puzzle we're going to switch up the task just a little. Now we want to target the Voltage Sensing Domain (VSD) of KCNQ1. It has been found that mutations to the VSD affect how effectively a protein is transported from its site of synthesis to the plasma membrane also known as trafficking. See blog post for more details, but note that we are looking at a different target site for KCNQ1 for this puzzle.

2501: Refine Density Reconstruction 4

This is a protein we've given before in puzzle 2137, which was Reconstruction Puzzle 7, but now we have the Refine Density tool available to make folds even better! Learn about the new tool here: https://fold.it/forum/blog/new-tool-refine-density. This one won't allow loading solutions from that puzzle.

2502: Revisiting Puzzle 70: Nucleosome Protein

This is a throwback puzzle to the early days of Foldit. This protein domain is a component of the histone protein complex, which packages DNA into compact units called nucleosomes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

2500: KCNQ1 Round 9

KCNQ1 is a critical gene that helps regulate the heart's rhythm by encoding the Kv7.1 potassium ion channel. Mutations in KCNQ1 can cause congenital long QT syndrome (LQTS), an inherited heart condition that increases the risk of sudden cardiac death, especially in young people. In this puzzle, your challenge is to design a new activator for KCNQ1 that can restore function in variants linked to LQTS. For this puzzle we're going to switch up the task just a little. Now we want to target the Voltage Sensing Domain (VSD) of KCNQ1. It has been found that mutations to the VSD affect how effectively a protein is transported from its site of synthesis to the plasma membrane also known as trafficking. See blog post for more details, but note that we are looking at a different target site for KCNQ1 for this puzzle.

2499: Electron Density Reconstruction 102

The structure of this protein has already been solved and published, but close inspection suggests that there are some problems with the published solution. We'd like to see if Foldit players can use the same electron density data to reconstruct a better model. For this first round of this puzzle, we won't have the Refine Density tool active. It is a bit large, so the Trim tool may be necessary.