Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
-
Have you ever stayed up at night wondering how you can bind biotin in a non-streptavadin protein scaffold? I know I sure have. Well, now you're in luck! With the new and improved "Hold Me Tighter" puzzle (A welcome improvement to the widely popular "Hold Me Tightly" puzzle) you can put those late night thoughts to good use! In this puzzle we have 3 scaffolds to choose from. (When you reset the puzzle, a random scaffold will appear). Scaffold 1: 1cbs: A cellular retionic-acid-binding protein; Scaffold 2: 1igs: A glycerolphosphate synthase; Scaffold 3: 1n9l: A phot-LOV1 domain. 3X the scaffolds equals 3X the fun! Your puzzle score is determined by the best scoring ligand in any of the three scaffolds, so give them all a try. Some scaffolds may be easier than others, but the best score could be in any of them.
-
Here is the next Mini-CASP target whose solved structure will be released soon. Again we are giving you an extended chain to see what you come up with. This might be difficult since this chain has 149 residues, so we will release Rosetta predictions for this target next week. Until then, good luck freestyle folding! The secondary structure prediction will be posted in the puzzle comments.
-
Here are the top 5 Rosetta@home predictions for Mini-CASP 6. This is a difficult de-novo (or ab-initio) target. This means that there is no solved structure that has a similar sequence that we were able to start our Rosetta@home predictions from. This is exciting because template-free targets are rare (in CASP8 only 11 of the 128 targets were free-modeling targets) so we are lucky to be able to predict this! Each time you reset the puzzle one of these top 5 Rosetta@home predictions will be randomly chosen, we hope you will try them all.
-
Here are the top 5 Rosetta@home predictions for Mini-CASP 6. This is a difficult de-novo (or ab-initio) target. This means that there is no solved structure that has a similar sequence that we were able to start our Rosetta@home predictions from. This is exciting because template-free targets are rare (in CASP8 only 11 of the 128 targets were free-modeling targets) so we are lucky to be able to predict this! Each time you reset the puzzle one of these top 5 Rosetta@home predictions will be randomly chosen, we hope you will try them all. For players with less than 15 global points.
-
Here are the top 5 Rosetta@home predictions for Mini-CASP 6. This is a difficult de-novo (or ab-initio) target. This means that there is no solved structure that has a similar sequence that we were able to start our Rosetta@home predictions from. This is exciting because template-free targets are rare (in CASP8 only 11 of the 128 targets were free-modeling targets) so we are lucky to be able to predict this! Each time you reset the puzzle one of these top 5 Rosetta@home predictions will be randomly chosen, we hope you will try them all. For players with less than 150 global points.
-
Sure, streptavadin has been the most popular biotin binding protein so far. However, we don't think it has to be that way and we want to knock biotin off its high horse. In this puzzle, we took a cellular retinoic-acid-binding protein and we are re-designing it to bind biotin instead of its native ligand. You will want to expand the hydrogen bonding network around the nitrogen containing end of biotin and pack the rest as best you can. The ligand score (obtained by pressing "tab" over the ligand) is a very good indicator of how well your ligand is bound. Bind biotin today, save the world tomorrow?
-
We would like you to refine your solutions from miniCASP5-Freestyle. There are 9 different starting structures, each time you reset the puzzle one of these 9 starts will be randomly chosen. The correct native solution is probably very different from the top scoring starting Foldit model, so we hope you will try to refine ALL of the 9 starting points.
-
We would like you to refine your solutions from miniCASP5-Freestyle. There are 9 different starting structures, each time you reset the puzzle one of these 9 starts will be randomly chosen. The correct native solution is probably very different from the top scoring starting Foldit model, so we hope you will try to refine ALL of the 9 starting points. For players with less than 15 global points.
-
We would like you to refine your solutions from miniCASP5-Freestyle. There are 9 different starting structures, each time you reset the puzzle one of these 9 starts will be randomly chosen. The correct native solution is probably very different from the top scoring starting Foldit model, so we hope you will try to refine ALL of the 9 starting points. For players with less than 150 global points.
-
In this puzzle, a protein is attaching to a piece of DNA. There are several mutatable regions on the protein, can you use those to get a better score?
