Foldit Puzzles

1017: 85 Residue Monomer Design: More Sheets!

This puzzle uses the updated Core Existence filter, and has a slightly lower threshold for identifying "core" residues. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1015: Revisiting Puzzle 146: Rosetta Decoy 9

This is a throwback puzzle to the early days of Foldit. This protein is a phosphatase that participates in several metabolic pathways. The starting structure is a Rosetta model. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1014: 75 Residue Monomer Design: Core Existence

In this puzzle, we've updated the way the Core Existence filter identifies core residues. The new method is more similar to what is used in the Baker Lab, and should also be a little faster. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1012: Unsolved De-novo Freestyle

We are giving you this unsolved vascular endothelial growth factor protein as a freestyle puzzle to start. We will post another round for this protein later, giving you server predictions as starting models, but we'd like you to just work with this extended chain for now (as homology-based methods have failed to solve this protein). More info in the puzzle comments, including a blogpost about this unsolved protein.

1013: Revisiting Puzzle 144: Rosetta Decoy 8

This is a throwback puzzle to the early days of Foldit. The function of this thermophilic protein is unknown, but it is unusual among intracellular proteins in that the native structure includes disulfide bonds. The starting structure is a Rosetta model. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1011: De-novo Freestyle 46: Low Power

NOTE: This puzzle was posted in error and has been closed prematurely. No points will be awarded for this puzzle.

1010: Abeta Binder Redesign

Help us design a binder for the Abeta peptide, a peptide associated with Alzheimer's disease! This starting structure was partially derived from Puzzle 811 results, with two extra β-strands flanking the central β-sheet. In addition, the connectivity of secondary structure elements has been altered, with new loops in several places. This puzzle has two filters: the Residue IE Score filter monitors that all PHE, TYR, and TRP residues are scoring well, and the SS Design filter prohibits GLY in sheets and helices. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

1009: Revisiting Puzzle 143: Rosetta Decoy 7

This is a throwback puzzle to the early days of Foldit. This enzyme helps to regenerate a cofactor that is necessary for nucleic acid synthesis. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1008: De-novo Freestyle 45: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. See the puzzle comments for secondary structure predictions!

1007: 90 Residue Monomer Design: SS Design

In natural proteins, different amino acids show different propensities for forming secondary structures like alpha helices and beta strands. This puzzle includes a new SS Design filter that restricts the use of GLY residues in helices and sheets. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!