Foldit Puzzles

1035: Incredibly Difficult 95-residue Electron Density Design Puzzle

This puzzle is unlike anything we have ever posted before! We have given you extremely accurate electron density, but no sequence information. This protein has 95-residues, but your starting model only has 5 Alanines that are floating in the density. You'll need to insert residues and mutate them as you make your way through the density. We know this won't be easy, some might even suggest that this task is impossible... but we know that if anyone can do it: you can!

1038: Revisiting Puzzle 54: Human Fyn

This is a throwback puzzle to the early days of Foldit. This kinase protein is part of a human signaling pathway that controls cell growth. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1037: 50 Residue Symmetric Pentamer Design

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1036: De-novo Freestyle 46: Round 2

This is Round 2 for Puzzle 1032. You will be able to load in your manual saves from 1032 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 1032, you can go back to 1032, manually save it, and the solution should appear in your manual saves for this puzzle.

1034: Revisiting Puzzle 52: Bacteria Energy

This is a throwback puzzle to the early days of Foldit. This protein is part of a metabolic pathway used by bacteria to harvest energy from sugars. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1033: 80 Residue Monomer Design: Zero Cysteines

In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1032: De-novo Freestyle 46: Hand-folding Round

It's been a while since our last hand-folding challenge! In this de-novo freestyle puzzle, only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be reposted with LUA scripts and sharing enabled. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

1031: Revisiting Puzzle 165: Rosetta Decoy 15

This is a throwback puzzle to the early days of Foldit. This protein helps to maintain the reduction potential of the cell, and is modeled here to form only one disulfide bond. The starting structure is a Rosetta model. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1029: 70 Residue Monomer Design: Zero Cysteines

In this puzzle, we're asking players to design a protein with no cysteine residues! Remember that the SS Design filter now considers the environment around each residue, in addition to secondary structure. This means that some residue types will be restricted depending on whether the position is in the core or surface of the protein. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1027: 80 Residue Symmetric Tetramer Design

NOTE: This puzzle has been closed and reposted as Puzzle 1027b.