Foldit Puzzles

990: Revisiting Puzzle 138: Rosetta Decoy 2

This is a throwback puzzle to the early days of Foldit. Ubiquitin is a well-known protein that helps to regulate the natural turnover of proteins in the cell, and this starting structure is a model of the protein produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

989: Post-CASP TR857: Quest to the Native

Our preliminary analysis suggests that very few players were able to improve the starting model of this CASP11 refinement target from Puzzle 956. We'd like to see if you can reach the native structure for this CASP refinement target when it's provided as a guide. Players may NOT load in solutions from Puzzle 956.

988b: Post-CASP Tc824: Relaxed Contacts

This contact map puzzle is based on the same CASP11 target as Puzzle 963, now with a relaxed distance threshold for contacts. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 4550 possible points from the filter. Players may not load in solutions from Puzzle 963, but they may load in solutions from the original Puzzle 988.

987b: Revisiting Puzzle 137: Rosetta Decoy

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate the human immune response, and the starting structure is a Rosetta model. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players may load in solutions from the original Puzzle 987.

986b: Post-CASP TR774: Quest to the Native

Our preliminary analysis suggests that very few players were able to improve the starting model of this CASP11 refinement target from Puzzle 924. We'd like to see if you can reach the native structure for this CASP refinement target when it's provided as a guide. Players may NOT load in solutions from Puzzle 924, but they may load in solutions from the original Puzzle 986.

978: Revisiting Puzzle 134: Rice

This is a throwback puzzle to the early days of Foldit. This protein shuttles lipids between cell membranes in the rice plant. Players will receive a bonus for forming up to four disulfide bonds in this puzzle. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.

976: Abeta binder full-length design

Due to CASP, it has been a while since we've posted an Alzheimer's disease puzzle. In this puzzle, we would like you to design a binder for the ABeta42 polypeptide that can bind to and stabilize the polypeptide in an alpha-helical conformation. You will get a bonus for forming up to three disulfide bonds.

977: Post-CASP Tc848: Server Model Contacts

This contact map puzzle is based on the same CASP11 target as Puzzle 965, and we want to see if you can improve a model from one of the competing servers. Instead of starting this puzzle with an extended chain, we've provided a model that satisfies a large number of contacts, but has some severe problems. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 2775 possible points from the filter. Players will NOT be able to load solutions from Puzzle 965.

975: Ebola glycoprotein 30-residue inhibitory peptide design

Based on player feedback, we are posting a second anti-Ebola peptide design puzzle, this time with a slightly longer peptide. We would like you to design a small (30-residue) peptide that can bind to and block the Ebola glycoprotein. The glycoprotein is a viral surface protein that allows the Ebola virus to enter human cells. A small peptide inhibitor of this protein would therefore represent a candidate therapeutic for treating this deadly disease. We are starting you with a hotspot "stub" that was the top-scoring result from the earlier stub-finding puzzle, number 846 (congratulations to AnthropicDreams). We have extended this stub with twenty-seven additional residues that you can design.

974: Revisiting Puzzle 126: Ethanolamine Utilization

This is a throwback puzzle to the early days of Foldit. This protein allows bacteria to metabolize ethanolamine and use it in constructing cell walls and cell membranes. The C-terminus of this protein is disordered in the starting model, but the rest of the protein is fairly close to the correct answer. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players will NOT be able to load in any previous solutions for these puzzles.