Foldit Puzzles

996: De-novo Freestyle 41: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

995: 70 Residue Monomer Design: SS Design

In natural proteins, different amino acids show different propensities for forming secondary structures like alpha helices and beta strands. This puzzle includes a new SS Design filter that restricts the use of GLY residues in helices and sheets. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

994: Revisiting Puzzle 139: Rosetta Decoy 3

This is a throwback puzzle to the early days of Foldit. This protein resolves aminoacyl-tRNA mismatches to reduce errors in protein translation; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

993: Post-CASP TR280: Quest to the Native

Our preliminary analysis suggests that very few players were able to improve the starting model of this CASP11 refinement target from Puzzle 921. We'd like to see if you can reach the native structure for this CASP refinement target when it's provided as a guide. Players may NOT load in solutions from Puzzle 921.

992: De-novo Freestyle 40: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

991: 60 Residue Monomer Design: SS Design

In natural proteins, different amino acids show different propensities for forming secondary structures like alpha helices and beta strands. This puzzle includes a new Secondary Structure Design filter that restricts the use of GLY residues in helices and sheets. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

990: Revisiting Puzzle 138: Rosetta Decoy 2

This is a throwback puzzle to the early days of Foldit. Ubiquitin is a well-known protein that helps to regulate the natural turnover of proteins in the cell, and this starting structure is a model of the protein produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

989: Post-CASP TR857: Quest to the Native

Our preliminary analysis suggests that very few players were able to improve the starting model of this CASP11 refinement target from Puzzle 956. We'd like to see if you can reach the native structure for this CASP refinement target when it's provided as a guide. Players may NOT load in solutions from Puzzle 956.

988b: Post-CASP Tc824: Relaxed Contacts

This contact map puzzle is based on the same CASP11 target as Puzzle 963, now with a relaxed distance threshold for contacts. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 4550 possible points from the filter. Players may not load in solutions from Puzzle 963, but they may load in solutions from the original Puzzle 988.

987b: Revisiting Puzzle 137: Rosetta Decoy

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate the human immune response, and the starting structure is a Rosetta model. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been. Players may load in solutions from the original Puzzle 987.