Foldit Puzzles

1010: Abeta Binder Redesign

Help us design a binder for the Abeta peptide, a peptide associated with Alzheimer's disease! This starting structure was partially derived from Puzzle 811 results, with two extra β-strands flanking the central β-sheet. In addition, the connectivity of secondary structure elements has been altered, with new loops in several places. This puzzle has two filters: the Residue IE Score filter monitors that all PHE, TYR, and TRP residues are scoring well, and the SS Design filter prohibits GLY in sheets and helices. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.

1009: Revisiting Puzzle 143: Rosetta Decoy 7

This is a throwback puzzle to the early days of Foldit. This enzyme helps to regenerate a cofactor that is necessary for nucleic acid synthesis. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1008: De-novo Freestyle 45: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. See the puzzle comments for secondary structure predictions!

1007: 90 Residue Monomer Design: SS Design

In natural proteins, different amino acids show different propensities for forming secondary structures like alpha helices and beta strands. This puzzle includes a new SS Design filter that restricts the use of GLY residues in helices and sheets. There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1006: Revisiting Puzzle 142: Rosetta Decoy 6

This is a throwback puzzle to the early days of Foldit. This protein was evolved in vitro to bind testosterone; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1005: De-novo Freestyle 44: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. Secondary structure predictions from the SAM server are currently unavailable, but the starting model includes secondary structure as predicted by PSIPRED.

1004: 70 Residue Design Refinement

In this puzzle we'd like you to refine a Foldit player-designed protein. The starting structure is an alternate conformation predicted for a design by stomjoh from Puzzle 995. We think this design shows promise, but it needs some tweaking. This puzzle includes an Exploration filter to keep players from straying too far from the starting structure. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1003: Revisiting Puzzle 141: Rosetta Decoy 5

This is a throwback puzzle to the early days of Foldit. This protein helps to regulate oxidation in the cell; the starting structure is a model produced by Rosetta. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1002: 22 Residue Peptide Design

This puzzle is aimed at designing short peptides that fold into stable structures. We encourage the use of multiple disulfide bonds, but discourage GLY residues, which will score especially poorly here. See the puzzle comments for more information about filters. The Baker lab will run folding predictions on your best designs, and the the ones that perform well will be synthesized and further validated for structural stability. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1001: De-novo Freestyle 43: Low Power

In this de-novo freestyle puzzle, the "High Wiggle Power" option has been disabled. The results from these puzzles will help us determine how useful the wiggle power options may be for structure prediction in Foldit. Secondary structure predictions from the SAM server are currently unavailable, but the starting model includes secondary structure as predicted by PSIPRED.