Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since almost 12 years ago964: CASP11 Refinement Target: TR848
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11964: CASP11 Refinement Target: TR848
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 138 residues. We've been told that ~59% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
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Closed since almost 12 years ago
962: CASP11 Target Tc818: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts962: CASP11 Target Tc818: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsFor this target, the CASP11 organizers have provided additional "correct" contact predictions, which we have combined with the sparse data contacts from Puzzle 949. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 4300 possible points from the filter. Players may load in solutions from Puzzle 949.
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Closed since almost 12 years ago
961: CASP11 Refinement Target: TR837
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11961: CASP11 Refinement Target: TR837
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 121 residues. We've been told that ~44% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
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Closed since almost 12 years ago
959: CASP11 Target Tc810: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts959: CASP11 Target Tc810: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsFor this target, the CASP11 organizers have provided additional "correct" contact predictions, which we have combined with the sparse data contacts from Puzzle 939. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 4425 possible points from the filter. Players may load in solutions from Puzzle 939.
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Closed since almost 12 years ago
960: CASP11 Refinement Target: TR854
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11960: CASP11 Refinement Target: TR854
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 70 residues. We've been told that ~60% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
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Closed since almost 12 years ago
963: CASP11 Target Tc824: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts963: CASP11 Target Tc824: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsFor this target, the CASP11 organizers have provided additional "correct" contact predictions, which we have combined with the sparse data contacts from Puzzle 951. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 4550 possible points from the filter. Players may load in solutions from Puzzle 951.
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Closed since almost 12 years ago
958: CASP11 Target Ts827: Sparse Data Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts958: CASP11 Target Ts827: Sparse Data Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsFor this target, the CASP11 organizers have provided "sparse" experimental data about possible contacts in the protein. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 3700 possible points from the filter. The starting structure is an extended chain; secondary structure predictions are unavailable at this time, but check back soon for updates!
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Closed since almost 12 years ago
957: CASP11 Refinement Target: TR856
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11957: CASP11 Refinement Target: TR856
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 159 residues. We've been told that ~62% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
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Closed since almost 12 years ago
956: CASP11 Refinement Target: TR857
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11956: CASP11 Refinement Target: TR857
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 96 residues. We've been told that ~34% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
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Closed since almost 12 years ago
This design puzzle uses a Secondary Structure filter similar to that of Puzzle 937. Players will receive a 500 point bonus if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. There are 3 additional filters: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!