Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Our 33rd CASP target puzzle has no templates. We are giving you the 5 Rosetta Server predictions as starting points and they are also in your template reserve so that you can use partial threading. Every group competing in CASP has access to these 5 server models too, so in order for Foldit to beat everyone else you'll need to significantly change these starting models, do not just refine them! NOTE: This puzzle ends on Friday!
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Our 32nd CASP target puzzle has 10 templates. You'll need to look at where the 10 different templates agree and try using the partial threading. Remember: the template with the top alignment score might not be the best one! You can also try partial threading with your saved solutions!
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Our 31st CASP target puzzle has 6 templates, but they don't span the entire protein. You'll need to look at where the 6 different templates agree, move the different alignments around where they don't, and try using the partial threading as well. For the unaligned end of the protein, you'll need to use all your folding skills!
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Our 30th CASP target puzzle is a bit different than the others. We believe that this protein is a coiled coil (http://en.wikipedia.org/wiki/Coiled_coil) so we are giving you the top Rosetta Server prediction as a starting point (but we are giving you 2 copies of it so that you can form a coiled coil). This is very similar to Intro Puzzle 5-5: Movin' Along, so make sure to play that level to refresh your memory.
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Our 29th CASP target puzzle has no templates. We are giving you the 5 Rosetta Server predictions as starting points (they are also in your template reserve so that you can use partial threading). All the other groups competing in CASP have access to these 5 server models as well, so you will need to significantly change these starting models (do not just refine them) in order for Foldit to beat everyone else!
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Our 28th CASP target puzzle has 5 templates but they don't span the entire protein. You'll need to look at where the 5 different templates agree, move the different alignments around where they don't, and try using the partial threading as well. For the unaligned end of the protein, you'll need to use all your folding skills!
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Our 27th CASP target is a tough one. It has 5 templates, but they do not span the entire protein. To help you with the unaligned regions we are putting the 5 Rosetta Server models in your template reserve. If you want Foldit to do well at CASP it is important not to just refine these server models, but try to find different topologies. Try out the 5 templates and use partial threading on the server models for the unaligned region.
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Our 26th CASP target puzzle is a big protein, but only has 1 template. Two of the chains in this template align well to our target, so we are giving you 2 different possible alignments for each chain (chain A and chain C).
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Our 25th CASP target puzzle has 8 templates! One of these templates is the recently solved structure from CASP9 Puzzle 2, PDB code: 3MQO. Partial threading should be very useful with so many templates, and please do try out all 8 templates. NOTE: This puzzle closes at an early time of day!
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Our 24th CASP target puzzle only has 1 template. We believe that the solution to this target folds up in a very similar way to the template, but we are uncertain of the alignment. So we have given you 3 different alignments to the exact same template structure. None of them thread particularly well but we hope that you will be able to pick the closest one, move the alignment around a bit, and find the correct fold!
