Foldit Puzzles

1074: Revisiting Puzzle 68: Bos Taurus

This is a throwback puzzle to the early days of Foldit. This cow protein, found in epithelial cells of the intestine, binds calcium as it moves from the digestive tract into the blood. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1073: Marburg Binder Design with Disulfides

Marburgvirus is a close relative of ebolavirus, and is similarly prone to epidemics in humans and primates. This is a design puzzle with 37 residues, near the interface of a target glycoprotein from the Marburg virus. At the binding site of the Marburg protein, there is already a beta hairpin derived from a human antibody. Build a scaffold around the starting design that will fold up properly and stabilize the binding hairpin! There are strong constraints to keep the hairpin residues in place, and you may not mutate residues at the interface. Players will receive an (extremely) large bonus for making up to 2 disulfide bonds. Remember to share your favorite designs using the Share with Scientist tool, even if those are not your best-scoring solutions!

1071: Blind Electron Density 10: Rosetta Model

This is the same target that players folded in Puzzle 1055, but here the starting solution is a Rosetta model. The density map, although derived from the same experimental data, will also appear different in this puzzle. Players will not be able to load in solutions from Puzzle 1055.

1072: Revisiting Puzzle 67: Integrase

This is a throwback puzzle to the early days of Foldit. This DNA-binding domain is part of a bacterial integrase protein, which facilitates the insertion of new DNA into the bacterial chromosome. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1070: 75 Residue Symmetric Dimer Design

Design a protein dimer with C2 cyclic symmetry! This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1069: Revisiting Puzzle 66: Cytochrome

This is a throwback puzzle to the early days of Foldit. This protein helps to transfer electrons between substrates in bacteria. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1067: Unsolved VEGF protein: Domain 1

The first two puzzles for this protein were able to significantly improve the structure of domain 6 of this protein, so we are giving you a different domain this time, with 5 Zhang Server predictions as starting points. Resetting the puzzle will cycle through each model. We are giving you 2 weeks to work on this puzzle, so please try out each server start. Although one server model scores better than the rest initially, it might be the furthest from the native and might not get you the most points in the end! More info in the puzzle comments.

1068: 70 Residue Symmetric Dimer Design

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1066: Revisiting Puzzle 64: Thioredoxin

This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (without disulfides bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1065: 90 Residue Monomer Design: Zero Cysteines

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!