Foldit Puzzles

1068: 70 Residue Symmetric Dimer Design

This puzzle again uses separate "Core Existence" filters for the monomer unit and the symmetric complex. Click the "Show" checkbox beneath the Core Existence filter to see which residues have been identified as Core (orange), Boundary (green), or Surface (blue). There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1066: Revisiting Puzzle 64: Thioredoxin

This is a throwback puzzle to the early days of Foldit. This human protein helps to regulate the reduction potential of the cell, and should be modeled here in reduced form (without disulfides bonds). We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1065: 90 Residue Monomer Design: Zero Cysteines

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1064: De-novo Freestyle 49: Round 2

NOTE: This puzzle has been closed and reposted as Puzzle 1064b.

1064b: De-novo Freestyle 49: Round 2

This is Round 2 for Puzzle 1061. You will be able to load in your manual saves from 1061 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 1061, you can go back to 1061, manually save it, and the solution should appear in your manual saves for this puzzle.

1063: Revisiting Puzzle 63: Spinach Protein

This is a throwback puzzle to the early days of Foldit. This spinach protein is critical for photosynthesis, and participates in the electron transfer chain within the chloroplast. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1062: 85 Residue Monomer Design: Zero Cysteines

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1061: De-novo Freestyle 49: Hand-folding Round

In this de-novo freestyle puzzle, only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be reposted with LUA scripts and sharing enabled. The PSIPRED secondary structure predictions are provided on the starting model.

1060: Revisiting Puzzle 62: Halorhodopsin

This is a throwback puzzle to the early days of Foldit. This protein is able to absorb light and use the energy to transfer chloride ions across the cell membrane. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1059: Player-Solution Trimer Redesign B

See if you can improve this Foldit player-designed protein! The starting structure is a Scientist-Shared solution designed by viosca in Puzzle 1052. We don't want players to stray too far from the initial design, so there's an Exploration filter to keep solutions close to the starting structure. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!