Foldit Puzzles

1084: De-novo Freestyle 50: Round 2

This is Round 2 for Puzzle 1081. You will be able to load in your manual saves from 1081 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. NOTE: If you did not manually save a solution in puzzle 1081, you can go back to 1081, manually save it, and the solution should appear in your manual saves for this puzzle.

1083: Revisiting Puzzle 71: Crystallin

This is a throwback puzzle to the early days of Foldit. This protein is found in high concentrations in the lens of the eye. Among its other functions, it is responsible for the high refractive index (and resulting optical properties) of the lens. The protein is modeled here in reduced state, so no disulfides are expected to form. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1082: Player-Solution Redesign

See if you can improve this Foldit player-designed protein! This protein was a top-scoring solution by Museka for Puzzle 1007. Scientists here at the Baker Lab see a lot of potential in this initial design, but want to see if other Foldit players can improve upon it. Note that this puzzle includes an Exploration Filter—changing the shape of the protein too much will disqualify your solution!

1081: De-novo Freestyle 50: Hand-folding Round

In this de-novo freestyle puzzle, only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be reposted with LUA scripts and sharing enabled. The PSIPRED secondary structure predictions are provided on the starting model.

1080: Revisiting Puzzle 70: Nucleosome Protein

This is a throwback puzzle to the early days of Foldit. This protein domain is a component of the histone protein complex, which packages DNA into compact units called nucleosomes. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1079: Blind Electron Density 11

This protein was designed in the Baker Lab, but we've had a lot of difficulty solving its crystal structure! Use all your Electron Density folding skills to fit the density as well as you can.

1078: 90 Residue Monomer Design: More Sheets!

In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

1077: Revisiting Puzzle 69: Scorpion Toxin

This is a throwback puzzle to the early days of Foldit. This is another potent neurotoxin produced by scorpions, similar to that found in Puzzle 55. This protein contains eight cysteine residues that oxidize to form four disulfide bonds. We are revisiting old Foldit puzzles so we can see how useful the recent additions to the game have been.

1076: Vancomycin Binder Design

Design a binding pocket for vancomycin! Scientists in the Baker Lab are trying to design proteins that can bind vancomycin and upon binding generate a signal. With this technology it would be possible to test patients that have been treated with antibiotics if they still have small amounts left before they leave e.g. a hospital. The aim of this puzzle is to optimize the interaction between a protein and the small molecule vancomycin. This puzzle has four different starting structures, all with slightly different residues at the binding site; resetting the puzzle will cycle through the different models.

1075: 75 Residue Monomer Design: More Sheets!

In this puzzle, we're asking players to design a protein with no cysteine residues, and extra beta sheets! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!