Foldit Puzzles

922: CASP11 Refinement Target: TR780

This CASP refinement target has 95 residues. We've been told that ~54% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.

921: CASP11 Refinement Target: TR280

This CASP refinement target has 96 residues, and we've been told that ~59% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.

919: 70 Residue Monomer Design: Strand Constraints

This is a single-chain design puzzle very similar to Puzzle 887, with four residues pre-folded into beta-strand conformation. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-strand conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 25% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

920b: CASP11 Target Ts785: Sparse Data Contacts

NOTE: THIS PUZZLE IS CLOSING EARLIER THAN ORIGINALLY SCHEDULED! This puzzle is a repost of Puzzle 920 which included an erroneous contact map. The set of predicted contacts has been improved for this puzzle, and the Contact Filter has been activated. Players may load in solutions from Puzzle 920.

918: Extra Credit CASP11 T0804: WeFold

Our WeFold collaborators are asking for your help! They have identified a server model that shows promise, but is clearly an unproteinlike prediction. Because this CASP11 target is so large, our WeFold collaborators tried to manually fix this server prediction on their own... but they are certain that you can do much better than them! We are giving you both the ugly server model and the manual WeFold prediction (along with the Alignment Tool). Since this target is too big to be a regular Foldit puzzle, we are posting it as an 'Extra Credit' CASP11 puzzle. It is only worth 10 points with no categories. More details in the puzzle comments.

916: CASP11 T0803: WeFold Round

For this 139 residue CASP11 Target, T0803, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them. Secondary structure predictions are in the puzzle comments.

917: CASP11 T0802: WeFold Round

For this 122 residue CASP11 Target, T0802, we are starting you off with only 2 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them. Secondary structure predictions are in the puzzle comments.

915: CASP11 Refinement Target: TR769

This CASP refinement target has 97 residues, and we've been told that ~60% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.

914: CASP11 Tc763: True Contacts

For this target, the CASP11 organizers have provided additional "correct" contact predictions, which we have combined with the sparse data contacts from Puzzle 907b. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 2085 possible points from the filter. Contact predictions are provided only for residues 31-160, so focus on that region of the protein! Players may load in solutions from Puzzles 888, 894, and 907b. Please note the short CASP deadline for this target!

913: CASP11 T0797: WeFold Docking

This 44 residue CASP11 Target is a little different, because T0797 and T0798 are two parts of the same complex. In this puzzle, we are giving you Robetta's T0797 prediction to model against a frozen server prediction for T0798, which was selected by our WeFold collaborators. The backbone of the larger T0798 region is completely frozen for this puzzle, so your job is to dock the short T0797 model against T0798 as best you can! More details in the puzzle comments.