Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
-
Closed since almost 12 years ago925: CASP11 Target Tc785: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts925: CASP11 Target Tc785: True Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsFor this target, the CASP11 organizers have provided additional "correct" contact predictions, which we have combined with the sparse data contacts from Puzzle 920b. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 985 possible points from the filter. Players will NOT be able to load in solutions from previous puzzles. See the puzzle comments for secondary structure predictions!
-
Closed since almost 12 years ago
924: CASP11 Refinement Target: TR774
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11924: CASP11 Refinement Target: TR774
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 155 residues. We've been told that ~39% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
-
Closed since almost 12 years ago
923: CASP11 Refinement Target: TR283
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11923: CASP11 Refinement Target: TR283
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 168 residues. We've been told that ~41% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
-
Closed since almost 12 years ago
For this target, the CASP11 organizers have provided "sparse" experimental data about possible contacts in the protein. Contacts are factored directly into your score in this puzzle, and contribute to the "Backbone" subscore. The starting structure is an extended chain, and secondary structure predictions can be found below in the puzzle comments.
-
Closed since almost 12 years ago
922: CASP11 Refinement Target: TR780
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11922: CASP11 Refinement Target: TR780
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 95 residues. We've been told that ~54% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
-
Closed since almost 12 years ago
921: CASP11 Refinement Target: TR280
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11921: CASP11 Refinement Target: TR280
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 96 residues, and we've been told that ~59% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle.
-
Closed since almost 12 years ago
This is a single-chain design puzzle very similar to Puzzle 887, with four residues pre-folded into beta-strand conformation. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-strand conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 25% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
-
Closed since almost 12 years ago
920b: CASP11 Target Ts785: Sparse Data Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts920b: CASP11 Target Ts785: Sparse Data Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsNOTE: THIS PUZZLE IS CLOSING EARLIER THAN ORIGINALLY SCHEDULED! This puzzle is a repost of Puzzle 920 which included an erroneous contact map. The set of predicted contacts has been improved for this puzzle, and the Contact Filter has been activated. Players may load in solutions from Puzzle 920.
-
Closed since almost 12 years ago
Our WeFold collaborators are asking for your help! They have identified a server model that shows promise, but is clearly an unproteinlike prediction. Because this CASP11 target is so large, our WeFold collaborators tried to manually fix this server prediction on their own... but they are certain that you can do much better than them! We are giving you both the ugly server model and the manual WeFold prediction (along with the Alignment Tool). Since this target is too big to be a regular Foldit puzzle, we are posting it as an 'Extra Credit' CASP11 puzzle. It is only worth 10 points with no categories. More details in the puzzle comments.
-
Closed since almost 12 years ago
916: CASP11 T0803: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11916: CASP11 T0803: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11For this 139 residue CASP11 Target, T0803, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them. Secondary structure predictions are in the puzzle comments.