Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since almost 12 years agoThis is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!
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Closed since almost 12 years ago
NOTE: This is a repost of Puzzle 898, with the Fragment Filter removed.
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Closed since almost 12 years ago
896: CASP11 T0769: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11896: CASP11 T0769: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11In this final round for CASP11 Target T0769, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them.
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Closed since almost 12 years ago
895: CASP11 T0765: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11895: CASP11 T0765: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11For the 128 residue CASP11 Target T0765, we are giving you 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them. Secondary structure predictions are in the puzzle comments.
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Closed since almost 12 years ago
894: CASP11 T0763: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11894: CASP11 T0763: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11In this final round for CASP11 Target T0763, we are starting you off with 1 server prediction selected by our WeFold collaborators. Many more details in the puzzle comments.
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Closed since almost 12 years ago
The first CASP11 refinement target is larger than most Foldit puzzles, at 201 residues. This model was the best server prediction for target T0760, generated by the MULTICOM-NOVEL server. We've been told that ~58% of this model matches the native! As this is such a large protein, we are giving you 10 days to work on it. More info in the puzzle comments, where you can post your feedback about whether puzzles of this size are too much for us to tackle in CASP11.
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Closed since almost 12 years ago
892: CASP11 Target T0773: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11892: CASP11 Target T0773: Server Models
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP11 target has only 70 residues! We've provided you with 5 Robetta server models. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them. See the puzzle comments for secondary structure predictions!
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Closed since almost 12 years ago
This is a single-chain design puzzle with 80 residues, and eight of the residues are pre-folded into a beta-hairpin. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-hairpin conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!
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Closed since about 12 years ago
893: CASP11 Target T0769: High Power
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11893: CASP11 Target T0769: High Power
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This is a repost of Puzzle 889, now with High Wiggle Power enabled. This CASP11 target has 106 residues, and the Robetta server has converged on a single structure. Players will be able to load in solutions from Puzzle 889. NOTE: If you did not manually save a solution in Puzzle 889, you can go back to 889 and manually save your solution to see it in your available solutions for this puzzle.
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Closed since about 12 years ago
890b: CASP11 T0759: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11890b: CASP11 T0759: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11Repost of Puzzle 890 where we have added one more server model. You will be able to load in solutions from Puzzle 890.