Foldit Puzzles

894: CASP11 T0763: WeFold Round

In this final round for CASP11 Target T0763, we are starting you off with 1 server prediction selected by our WeFold collaborators. Many more details in the puzzle comments.

897: Large CASP11 Refinement Puzzle: TR760

The first CASP11 refinement target is larger than most Foldit puzzles, at 201 residues. This model was the best server prediction for target T0760, generated by the MULTICOM-NOVEL server. We've been told that ~58% of this model matches the native! As this is such a large protein, we are giving you 10 days to work on it. More info in the puzzle comments, where you can post your feedback about whether puzzles of this size are too much for us to tackle in CASP11.

892: CASP11 Target T0773: Server Models

This CASP11 target has only 70 residues! We've provided you with 5 Robetta server models. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them. See the puzzle comments for secondary structure predictions!

891: 80 Residue Monomer Design: Hairpinned

This is a single-chain design puzzle with 80 residues, and eight of the residues are pre-folded into a beta-hairpin. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-hairpin conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

893: CASP11 Target T0769: High Power

This is a repost of Puzzle 889, now with High Wiggle Power enabled. This CASP11 target has 106 residues, and the Robetta server has converged on a single structure. Players will be able to load in solutions from Puzzle 889. NOTE: If you did not manually save a solution in Puzzle 889, you can go back to 889 and manually save your solution to see it in your available solutions for this puzzle.

890b: CASP11 T0759: WeFold Round

Repost of Puzzle 890 where we have added one more server model. You will be able to load in solutions from Puzzle 890.

888: CASP11 Target T0763: Server Models

This CASP11 target has 163 residues, and we've provided you with 5 Robetta server models. Restart the puzzle to cycle through the alternate starting structures. See the puzzle comments for secondary structure predictions!

889: CASP11 Target T0769: Server Model

This CASP11 target has 106 residues, and the Robetta server has converged on a single structure. We've provided the Robetta prediction as the starting model, but feel free to explore other structures! See the puzzle comments for secondary structure predictions.

890: CASP11 T0759: WeFold Round (CLOSED and reposted as 890b)

This puzzle has been replaced by Puzzle 890b where you will be able to load in solutions from this puzzle. This puzzle will close in the next 24 hours...

887: 70 Residue Monomer Design: Strand Constrained

This is a single-chain design puzzle with 70 residues, and four of the residues are pre-folded into beta-strand conformation. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-strand conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 25% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!