Foldit Puzzles

904: CASP11 T0785: WeFold Round

For this 115 residue CASP11 Target, T0785, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model. Please try out each server start. Although one server model scores better than the rest initially, it might be the furthest from the native and might not get you the most points in the end! Secondary structure predictions are in the puzzle comments.

903: Brain Cancer-Related Phosphorylated Id2

Researchers at Dartmouth College are trying to determine the structure of the Id2 protein, and have asked for Foldit's help! Id2 is a regulatory protein that has been implicated in some brain cancers. The N- and C-terminal tails of Id2 are very important for the protein's function, but the structure of these regions is unknown. Help determine the structure of this Id2's tail regions in its symmetric dimer form! The central helices of this protein are held in place by constraints, although some slight movement is allowed. Also, note that the serine at position 14 has a negatively charged phosphate group attached. Read the blogpost for more info!

902: Bonus CASP11 T0779 Symmetry Puzzle

The CASP organizers have told us that this small protein is a dimer, so we are posting a Bonus Round for T0779 as a symmetric dimer! Resetting the puzzle will cycle through each model. More info in the puzzle comments.

901: CASP11 T0779: WeFold Round

For this 62 residue CASP11 Target, T0779, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model. As this is a small protein, please try out each server start. The topology that initially scores poorly may actually be the closest to the native and could eventually score better than everything else. Conversely, the starting model that scores the best initially, may not get you the most points in the long run!

900: Small CASP11 Refinement Puzzle: TR759

Our 900th Foldit puzzle might bring up some Déjà vu. Not only will this 62 residue amino acid sequence look familar, but so should the starting model. This model was the best server prediction for target T0759, generated by the nns server. We've been told that ~45% of this model matches the native! More exciting info in the puzzle comments.

899: CASP11 T0773: WeFold Round

In this final round for CASP11 Target T0773, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model. As this is a small protein, please try out each server start. The topology that initially scores poorly may actually be the closest to the native and could eventually score better than everything else. Conversely, the starting model that scores the best initially, may not get you the most points in the long run!

898: 75 Residue Monomer Design: Weak Helices

This is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

898b: 75 Residue Monomer Design: Weak Helices

NOTE: This is a repost of Puzzle 898, with the Fragment Filter removed.

896: CASP11 T0769: WeFold Round

In this final round for CASP11 Target T0769, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them.

895: CASP11 T0765: WeFold Round

For the 128 residue CASP11 Target T0765, we are giving you 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them. Secondary structure predictions are in the puzzle comments.