Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since almost 12 years agoFor this target, the CASP11 organizers have provided "sparse" experimental data about possible contacts in the protein. Ironically, the "sparseness" of the data manifests as a huge number of possible contacts, with very little information about which contacts might be correct. Contacts are scored with the Contact Map filter in this puzzle, and there is an upper limit of 2029 possible points from the filter. Contact predictions are provided only for residues 31-160, so focus on that region of the protein! Players may load in solutions from Puzzles 888 and 894 and we've provided you with 5 Robetta server models. Restart the puzzle to cycle through the alternate starting structures.
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Closed since almost 12 years ago
907b: CASP11 Target Ts763: Sparse Data Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts907b: CASP11 Target Ts763: Sparse Data Contacts
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted Contacts Predicted ContactsNOTE: This puzzle replaces Puzzle 907, which included a much larger set of contact predictions. All contacts now have equal weight, and players should aim to satisfy as many contacts as possible.
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Closed since almost 12 years ago
906: HIV-1 Env gp41 CASP11 T0787: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11906: HIV-1 Env gp41 CASP11 T0787: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This 153 residue CASP11 Target is part of the HIV-1 Env complex. We are giving you 4 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model and they are available in the Alignment Tool so you can use partial threading between them.
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Closed since almost 12 years ago
905: CASP11 Refinement Target: TR782
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11905: CASP11 Refinement Target: TR782
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11This CASP refinement target has 110 residues. We've been told that ~65% of this starting structure is correct. High Wiggle Power has been enabled for this puzzle. Secondary structure predictions are in the puzzle comments.
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Closed since almost 12 years ago
904: CASP11 T0785: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11904: CASP11 T0785: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11For this 115 residue CASP11 Target, T0785, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model. Please try out each server start. Although one server model scores better than the rest initially, it might be the furthest from the native and might not get you the most points in the end! Secondary structure predictions are in the puzzle comments.
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Closed since almost 12 years ago
903: Brain Cancer-Related Phosphorylated Id2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry903: Brain Cancer-Related Phosphorylated Id2
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetryResearchers at Dartmouth College are trying to determine the structure of the Id2 protein, and have asked for Foldit's help! Id2 is a regulatory protein that has been implicated in some brain cancers. The N- and C-terminal tails of Id2 are very important for the protein's function, but the structure of these regions is unknown. Help determine the structure of this Id2's tail regions in its symmetric dimer form! The central helices of this protein are held in place by constraints, although some slight movement is allowed. Also, note that the serine at position 14 has a negatively charged phosphate group attached. Read the blogpost for more info!
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Closed since almost 12 years ago
902: Bonus CASP11 T0779 Symmetry Puzzle
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11902: Bonus CASP11 T0779 Symmetry Puzzle
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11The CASP organizers have told us that this small protein is a dimer, so we are posting a Bonus Round for T0779 as a symmetric dimer! Resetting the puzzle will cycle through each model. More info in the puzzle comments.
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Closed since almost 12 years ago
901: CASP11 T0779: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11901: CASP11 T0779: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11For this 62 residue CASP11 Target, T0779, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model. As this is a small protein, please try out each server start. The topology that initially scores poorly may actually be the closest to the native and could eventually score better than everything else. Conversely, the starting model that scores the best initially, may not get you the most points in the long run!
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Closed since almost 12 years ago
900: Small CASP11 Refinement Puzzle: TR759
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11900: Small CASP11 Refinement Puzzle: TR759
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11Our 900th Foldit puzzle might bring up some Déjà vu. Not only will this 62 residue amino acid sequence look familar, but so should the starting model. This model was the best server prediction for target T0759, generated by the nns server. We've been told that ~45% of this model matches the native! More exciting info in the puzzle comments.
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Closed since almost 12 years ago
899: CASP11 T0773: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11899: CASP11 T0773: WeFold Round
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP11 CASP11 CASP11 CASP11 CASP11 CASP11 CASP11In this final round for CASP11 Target T0773, we are starting you off with 5 different server predictions selected by our WeFold collaborators. Resetting the puzzle will cycle through each model. As this is a small protein, please try out each server start. The topology that initially scores poorly may actually be the closest to the native and could eventually score better than everything else. Conversely, the starting model that scores the best initially, may not get you the most points in the long run!