Foldit Puzzles
Play puzzles to help scientific research and compete with other players. New puzzles are posted every week.
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Closed since over 13 years ago648: Server models for R0021
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL648: Server models for R0021
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLAs mentioned in Puzzle 643, we are giving you server predictions for each CASP ROLL target. Resetting the puzzle will cycle through 10 different server predictions (this target is so tough, they are all different) and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start.
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Closed since over 13 years ago
646: Server models for R0020
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL646: Server models for R0020
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLAs mentioned in Puzzle 641, we are giving you server predictions for each CASP ROLL target. Resetting the puzzle will cycle through 7 different server predictions (that are similar to one another) and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else
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Closed since over 13 years ago
645: CASP ROLL Target R0023
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL645: CASP ROLL Target R0023
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLAnother CASP ROLL target. We are again providing you with 3 very different templates for now, and will give you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.
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Closed since over 13 years ago
This is a short 42-residue protein found in duckbilled platypus venom for new players to try out after completing the Introductory Puzzles. The native is shown as a guide on this puzzle, so try using everything you've learned in the Intro levels to match the native fold. The guide can be turned on/off with Shift-S.
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Closed since over 13 years ago
This particular puzzle is a test-run involving a potentially very useful hydrogen-producing catalyst, attached to four symmetric chains. For now, we just want to see what sorts of interesting structures you can come up with (see the new blogpost for more details). We’re using the "ResidueIE filter" again to make it tougher to expose hydrophobic residues and bury polar groups.
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Closed since over 13 years ago
643: CASP ROLL Target R0021
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL643: CASP ROLL Target R0021
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLHere is the next CASP ROLL target. We are again providing you with 3 templates for now, and will give you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.
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Closed since over 13 years ago
642: CASP ROLL Target R0022
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL642: CASP ROLL Target R0022
Closed Advanced Advanced Advanced Advanced Advanced Advanced Advanced Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLAnother CASP ROLL target. We are again providing you with 3 very different templates for now, and will give you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.
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Closed since over 13 years ago
641: CASP ROLL Target R0020
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL641: CASP ROLL Target R0020
Closed Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLL CASP ROLLCASP ROLL is back! We are providing you with 3 templates for now (in hope that one of them is correct), and will give you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.
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Closed since over 13 years ago
You've seen this design puzzle before, but look more closely! The Frizzled protein occurs in a number of forms. Last time we gave you a form of Frizzled with a narrow pocket. This time we are giving you a form of Frizzled with a wider pocket. There are a couple of rules: You can mutate any residue on the helix but none on Frizzled and the small binding helix must stay in helical shape. We've also added a new filter that we call "Residue Interaction Energy". Natural proteins avoid putting Tryptophan, Phenylalanine, and Tyrosine on the surface. However, Foldit often gives a score bonus if you load up the surface of your design with Tryptophan. The Residue Interaction Energy filter helps to counteract that, helping you make better designs. Enjoy and thanks for all of your efforts!
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Closed since over 13 years ago
This currently unsolved short protein does not have any templates that we can use, so to prepare for CASP ROLL we are giving it to you as an extended chain. Use all your skills to fold it up as best as you can. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.