Foldit Puzzles

658: Revisiting Puzzle 53

We are revisiting this E. Coli puzzle (http://fold.it/portal/node/212180). See how much better you can do with new techniques and recipes. Players will NOT be able to load in any previous solutions for these puzzles.

658 (<15): Revisiting Puzzle 53

We are revisiting this E. Coli puzzle (http://fold.it/portal/node/212180). See how much better you can do with new techniques and recipes. Players will NOT be able to load in any previous solutions for these puzzles.

658 (<150): Revisiting Puzzle 53

We are revisiting this E. Coli puzzle (http://fold.it/portal/node/212180). See how much better you can do with new techniques and recipes. Players will NOT be able to load in any previous solutions for these puzzles.

657: Blind Electron Density 3

This is our third electron density puzzle with real data. Like our second puzzle, we were able to pinpoint which regions belong to a single copy. Try to fit the protein into the density to get the best score!

654: Server models for R0025

As mentioned in Puzzle 653, we are giving you server predictions for this CASP ROLL target. Resetting the puzzle will cycle through 9 different server predictions and they are available in the Alignment Tool so you can use partial threading between them. Please try out each start, as the topology that initially scores poorly may actually be the closest to the native and will eventually score better than everything else.

Beginner Puzzle: Headpiece Domain of Chicken Villin

This is a Beginner puzzle for new players that have recently completed the Intro Puzzles. The starting model is stuck in a local minimum, can you use the Foldit tools you just learned to improve the model and match the guide?

656: 40 Residue Symmetric Trimer Retry

This is a small (40 residue) symmetric trimer design puzzle. It is the same as 623 except the Residue Interaction Energy filter is enabled. This filter will give a score bonus or penalty based on how well your residues are scoring compared to expected values.

655: Blind Electron Density 2

This is our second electron density puzzle with real data. This should be easier than our last density case, since the scientists were able to pinpoint which regions belonged to a single copy. Try to fit the protein into the density to get the best score!

653: CASP ROLL Target R0025

Here is the next CASP ROLL target. We are again providing you with 3 templates for now, and will give you with some server predictions once they are released. More details about this CASP target are in the puzzle comments.

652: 40 Residue Symmetry Dimer Retry

This is a small (40 residue) symmetric dimer design puzzle. It is the same as 617 except there are two new features added to create better designs. The Residue IE (Interaction Energy) filter will give a bonus or penalty based on how well your residues are scoring compared to expected values. The LayerDesign filter will restrict the types of amino acids to encourage more realistic designs. A symmetric protein relies not only on how well folded each part is, but also on how well they interface together; see the latest blogpost about this: http://fold.it/portal/node/993871