Foldit Puzzles

661: Malaria Puzzle

Help solve the structure of the PfRh5 malaria protein that binds to human red blood cells. Understanding the structure of this protein could help in the development of vaccines and therapeutics for malaria.

661 (<15): Malaria Puzzle

Help solve the structure of the PfRh5 malaria protein that binds to human red blood cells. Understanding the structure of this protein could help in the development of vaccines and therapeutics for malaria. For players with fewer than 15 global points.

661 (<150): Malaria Puzzle

Help solve the structure of the PfRh5 malaria protein that binds to human red blood cells. Understanding the structure of this protein could help in the development of vaccines and therapeutics for malaria. For players with fewer than 150 global points.

660: Return of the Multi-Start Pseudomonas Aeruginosa

We are giving you 5 server models for this currently unsolved protein. Each time you reset the puzzle one of these 5 Zhang server predictions will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta. More info about this protein in the puzzle comments.

660 (<15): Return of the Multi-Start Pseudomonas Aeruginosa

We are giving you 5 server models for this currently unsolved protein. Each time you reset the puzzle one of these 5 Zhang server predictions will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta. More info about this protein in the puzzle comments. For players with fewer than 15 global points.

660 (<150): Return of the Multi-Start Pseudomonas Aeruginosa

We are giving you 5 server models for this currently unsolved protein. Each time you reset the puzzle one of these 5 Zhang server predictions will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta. More info about this protein in the puzzle comments. For players with fewer than 150 global points.

Beginner Puzzle: Turkey Egg Lysozyme

This is a puzzle for new players that have just finished the tutorials. The protein is a Turkey Egg Lysozyme. Lysozymes damage the cell walls of bacteria. Try to match the protein to the native guide to increase your score!

659: Re-Return of the Tissue Regeneration Design Puzzle

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments.

659 (<15): Re-Return of the Tissue Regeneration Design Puzzle

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments. For players with fewer than 15 global points.

659 (<150): Re-Return of the Tissue Regeneration Design Puzzle

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments. For players with fewer than 150 global points.