Foldit Puzzles

668: Puzzle 665 Open Phase

This is a repost of puzzle 665. You will be able to load in your manual saves from 665 and use them as a starting point here. This puzzle has been opened up to allow for sharing and the use of all scripts. See if you can improve your model from the first round using these tools, or start from scratch! NOTE: If you did not manually save a solution in puzzle 665, you can go back to 665, manually save it, and the solution should appear in your manual saves for this puzzle.

666: Blind Electron Density 6

This is our sixth electron density puzzle with real data. This time we're giving you a starting model that has been generated by servers. There are bits of density which don't belong to the copy of the protein that you're working on. However, the protein you're working on should fit entirely within the density box. You'll have to decide which bits of density to match with, and which bits to ignore. Try to fit the protein into the density to get the best score!

665: Solo Hand-Folding Diversification Puzzle

This puzzle is the first in a series that we are running to observe how script use and sharing affect diversification. In this puzzle, only GUI scripts are allowed, and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You will be able to load in your solutions from the first puzzle and refine them with scripting and sharing.

664: Unlocked Frizzled Design Puzzle

This is a the same protein as Puzzle 640 (Frizzled with a wider pocket than Puzzle 659) but this time the helix is unlocked. You can mutate any residue on the helix but none on Frizzled. We still have the new "Residue Interaction Energy" filter. Natural proteins avoid putting Tryptophan, Phenylalanine, and Tyrosine on the surface. However, Foldit often gives a score bonus if you load up the surface of your design with Tryptophan. The ResidueIE filter helps to counteract that, helping you make more useful designs. More details in the puzzle comments.

663: Blind Electron Density 5

This is our fifth electron density puzzle with real data. Unlike the previous puzzles, there are bits of density which don't belong to the copy of the protein that you're working on. However, the protein you're working on should fit entirely within the density box. You'll have to decide which bits of density to match with, and which bits to ignore. Try to fit the protein into the density to get the best score! Secondary Structure Predictions are posted in the puzzle comments.

662: Blind Electron Density 4

This is our fourth electron density puzzle with real data. Like our previous puzzles, we were able to pinpoint which regions belong to a single copy, though the density itself is less clear. Try to fit the protein into the density to get the best score! Secondary Structure Predictions are posted in the puzzle comments.

661: Malaria Puzzle

Help solve the structure of the PfRh5 malaria protein that binds to human red blood cells. Understanding the structure of this protein could help in the development of vaccines and therapeutics for malaria.

661 (<15): Malaria Puzzle

Help solve the structure of the PfRh5 malaria protein that binds to human red blood cells. Understanding the structure of this protein could help in the development of vaccines and therapeutics for malaria. For players with fewer than 15 global points.

661 (<150): Malaria Puzzle

Help solve the structure of the PfRh5 malaria protein that binds to human red blood cells. Understanding the structure of this protein could help in the development of vaccines and therapeutics for malaria. For players with fewer than 150 global points.

660: Return of the Multi-Start Pseudomonas Aeruginosa

We are giving you 5 server models for this currently unsolved protein. Each time you reset the puzzle one of these 5 Zhang server predictions will randomly be chosen. They are also in the Alignment Tool so you can use partial threading and well as an extended chain. We would like to see how well you can refine these models that were not generated using Rosetta. More info about this protein in the puzzle comments.